Bordetella

Question 1

mention some species of bordetella and their diseases

Answer 1

pertussis, whooping couph
parapurtessis, less sever
bronchosepticus, bronchitis in dogs and animals, rarely man.

Question 2

aerobes? gram? spore? motile? capsule, granules?

Answer 2

strict, negative cocco bacilli, non spore forming, non motile, capsulated, bipolar metachromatic granules

Question 3

how can you differentiate bw differente species?

Answer 3

Biochemical reactions.
pertussis is oxidase +, urease -
para, oxidase -, ueruase +
bronco is + for both

Question 4

mention the viuralance factors of prtussis

Answer 4

1-Structural AG
filamentous haemagglutinin
fimberiae and pertactin
LPS

2_toxins: 
PT
Adenylate cyclase toxin
tracheal cytotoxix 
dermonecrotic toxin

Question 5

what’s the action of PT

Answer 5

A/B toxin
elevate 
T lymphositosis
the release of insulin 
IgE secretion 

inhibit leukocyte function

contribute to bacterial binding to cilliated epi.

Question 6

what’s the I. P and clinical manifestation of pertussis

Answer 6

7-10 days

three stages: catarrhal, paroxysmal, convalescent.

Question 7

how can we diagnose pertussis?

Answer 7

specimen: Nasal or Nasopharyngeal swap or cogh plate method.
1_microscopic exam.
2_culture: isolation is difficult, don’t grow in ordinary media.
Bordet and gengou media«potato blood glycerol agar,
charchol blood agar m «mercury drop appears
3_serology
4_pcR, specific antisera

Question 8

treatment and chemoprophylaxis?

Answer 8

erythromycin