Naloxone Flashcards
1
Q
What is the dose of naloxone?
A
0.4mg in 10ml fluid iv, repeat every 2 minutes up to 4 times
2
Q
Contraindications of naloxone
A
Hypersensitivity only
Caution in opiate dependence inc. newborns, may induce acute abstinence syndrome
3
Q
Side effects of naloxone
A
Patient likely v angry when wakes
Nausea, vomiting, sweating, tremor, cold turkey
4
Q
How is naloxone eliminated?
A
Glucuronated in liver, excreted in urine
5
Q
How does the half life of naloxone compare to that of morphine?
A
T1/2 of naloxone is shorter than for morphine so repeated dosing may be required
6
Q
How does naloxone work and what is it used for?
A
Opiate overdose or oversedation- competitively binds to mu-opioid receptors in CNS
