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Drugs- emergency and basic > Metronidazole > Flashcards

Metronidazole Flashcards

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Royal College: Emergency Medicine flashcards
1
Q

Which organisms are affected by metronidazole

A

Anaerobes

C difficile, giardia, trichomonas, entamoeba histolyticum, h pylori

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2
Q

Name some indications for metronidazole

A

Bacterial vaginosis, surgical prophylaxis, amoebiasis, trichomoniasis, c difficile

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3
Q

Contraindications of metronidazole

A

First trimester of pregnancy
Blood dyscrasia
Severe hepatic impairment
Recent alcohol/disulfiram

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4
Q

Side effects of metronidazole

A

Dizziness, headache
Diarrhoea, nausea, abdo pain
Change in taste, dry mouth
Dark urine- harmless

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5
Q

Which drugs interact with metronidazole?

A 
Alcohol - disulfiram type reaction
Disulfiram- psychosis
Potentiates warfarin
Cyp450 drugs
Lithium- increases levels
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6
Q

How is metronidazole metabolised?

A

Cyp450 system then renal excretion

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7
Q

How does metronidazole work?

A

Covalently binds to DNA inside anaerobic organism, stops nucleic acid synthesis

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Drugs- emergency and basic (21 decks)

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