Ipratropium Bromide Flashcards
What is the dose of ipratropium in acute severe asthma?
500microgram nebulised back to back with 5mg salbutamol
What is another indication for ipratropium?
COPD
What are the contraindications for ipratropium?
Hypersensitivity to ipratropium or atropine
Warnings: glaucoma, BPH, CF
Side effects of ipratropium
Headache, dizziness, dry mouth, blurred vision
Paradoxical bronchospasm (also salbutamol)
Urinary retention
Which drugs interact with ipratropium?
Additive effect with sympathomimetics and methylxanthines
How is ipratropium eliminated?
Active secretion into renal tubules
Half life 2-4 hours
How does ipratropium work?
Anticholinergic- blocks M3 muscarinic acetylcholine receptors, inhibiting parasympathetic bronchoconstriction