ACE inhibitors Flashcards
1
Q
Outline the renin angiotensin system
A
Renin converts angiotensinogen to AT1. ACE converts AT1 to AT2
2
Q
What are the effects of angiotensin 2?
A
Sympathetic activation, vasoconstriction, ADH and aldosterone release
3
Q
Where is ACE located?
A
Kidneys and lungs
4
Q
Indications for ACE inhibitor
A
Hypertension in under 55s
Heart failure with reduced ejection fraction
5
Q
Contraindications to ACE inhibitor
A
Afro-caribbean or elderly Impaired renal function or bilat RAS Pregnancy Previous angioedema Aortic stenosis
6
Q
Side effects of ACE inhibitor
A
Dry cough- bradykinin
Angioedema
First dose hypotension
Hyperkalaemia
7
Q
Which drugs interact with ACE inhibitors
A
Other BP tablets Diuretics esp spironalactone NSAIDs - cause AKI Anticoagulants Gliptins
8
Q
How do ACE inhibitors work?
A
Block angiotensin converting enzyme so angiotensin 2 not produced - sympathetic vasoconstriction/ADH/aldosterone blocked
