Naloxone

Question 1

Naloxone
Drug Class

Answer 1

An opioid antagonist that reverses the effects of opioids by competing with the same receptor sites.

Question 2

** Naloxone**
Onset

Answer 2

IV / IO: 1-3 minutes
IM: 3-5 minutes

Question 3

** Naloxone**
Duration

Answer 3

Approximately 60 minutes all routes

Question 4

** Naloxone**
Indications

Answer 4

Respiratory depression in a suspected narcotic overdose.

Question 5

** Naloxone**
Contraindications

Answer 5

Hypersensitivity to Naloxone

Question 6

Naloxone
Dose

Answer 6

Adult:
* IM- IV-IO
400 - 800mcg repeated every 2 mins (total max dose 10mg)

• IV / IO:
  Dilute 400microg in 1mL with 9mL NaCl 0.9% to produce 40microg/1mL*

IN
1 spray (1.8mg) Nyoxoid into nostrol
Repeat at 2 mins in opposite nostril if no response.

Paediatric:

IM/IV/IO:
10 microg/kg, (total max dose 400 mcg), repeat every 2-3 minutes as required, titrated to clinical response.

If high suspicion of overdose, 100 microg/kg dose (Total max 2mg) may be given following a lack of response to initial dose.

**IN: **
One spray (1.8mg) of Nyxoid® into nostril.
Repeat after 2 minutes if no response

Question 7

** Naloxone**
Side Effects

Answer 7

• Combativeness
• Vomiting
• Sweating
• Tachycardia
• Hypertension
• Acute withdrawal convulsions (chronic narcotic users)
• Pulmonary Oedema (rare)