Glyceryl Trinitrate

Question 1

Glyceryl Trinitrate
Drug Class

Answer 1

Vasodilator -increases venous capacity and pooling blood in the peripheral veins

Question 2

** Glyceryl Trinitrate**
Onset

Answer 2

Sublingual < 2 mins

Question 3

** Glyceryl Trinitrate**
Duration

Answer 3

20 – 30 mins

Question 4

** Glyceryl Trinitrate**
Indications

Answer 4

• Chest pain/discomfort of presumed cardiac origin not relieved by rest and reassurance with:
• Systolic BP > 90 mmHg
• Heart rate between 50-150 beats per minute
• Acute Cardiac Pulmonary Oedema with systolic BP > 90 mmHg
• Autonomic Dysreflexia with systolic BP > 160 mmHg

Question 5

** Glyceryl Trinitrate**
Contraindications

Answer 5

• Hypersensitivity to Glyceryl Trinitrate
• Hypotension < 90 mmHg
• Ventricular Tachycardia (VT)
• Recent use of medications for sexual dysfunction or pulmonary arterial hypertension:
  -Sildenafil (Viagra), Avanafil (Spedra) in previous 24hrs.
  -Tadalafil (Cialis) in previous 3 days
  -Riociguat (Adempas)

Question 6

** Glyceryl Trinitrate **
Chest Pain/Discomfort
Dose

Answer 6

• 400 microg (1 spray) sublingually
• Repeat every 5 mins if required if SBP >90mmHg

Question 7

** Glyceryl Trinitrate **
Acute Pulmonary Odema
Dose

Answer 7

• 400 microg (1 spray) sublingually
• Repeat every 5 mins if required if SBP >90mmHg

Question 8

** Glyceryl Trinitrate **
autonomic dysreflexia
Dose

Answer 8

• 400 microg (1 spray) sublingually
• Repeat every 5 mins if required until SBP <160 mmHg

Question 9

** Glyceryl Trinitrate**
Side Effects

Answer 9

Dizziness
Hypotension
Syncope
Reflex tachycardia
Vascular headaches