Droperidol

Question 1

** Droperidol**
Drug Class

Answer 1

Antipsychotic – Acts on the alpha and dopamine receptors, resulting in sedation

Question 2

** Droperidol **
Onset

Answer 2

IV/IM - 3 - 5 mins

Question 3

** Droperidol **
Duration

Answer 3

IV/IM - 4 - 6 hrs

Question 4

** Droperidol**
Indication

Answer 4

• Disturbed and Abnormal Behaviour (RASS 1 ~ 3) where risk to safety is evident and de escalation has not been effective.

Question 5

** Droperidol**
Contraindications

Answer 5

• Known allergy
• Known Parkinson’s Disease
• Post Ketamine
• Age < 6 years old
• Post-ictal Disturbed & Abnormal Behaviour

Question 6

** Droperidol **
Preparation

Answer 6

IM - Do not dilute
**IV **- Dilute 10/2ml with 8ml NaCL (1mg/ml)

Question 7

** Droperidol**
IM (preferred route)
Dose

Answer 7

Adult < 70 yrs
* 5mg (moderate to severe alcohol intoxication)
* 10 mg (nil to mild alcohol intoxication)

Repeat as necessary every 15 mins total max dose 20mg/24 hrs ( all routes)

Switch to IV midazolam only if necessary once total max dose is reached.

Adult > 70 yrs or frail, dementia patients

• 2.5mg (moderate to severe alcohol intoxication)
• 5mg (nil to mild alcohol intoxication)

Repeat as necessary every 15 mins total max dose 10mg/24 hrs ( all routes)

Switch to IV midazolam only if necessary once total max dose is reached.

Paediatric 6 - 16 yrs
0.2 mg/kg (max bolus 5mg)

Repeat as necessary every 15 mins total max dose 10mg/24 hrs (via all routes)

Question 8

** Droperidol**
IV
Dose

Answer 8

Adult < 70 yrs
* 2.5mg - 5mg titrated to effect

Repeat as necessary every 15 mins to a Total max dose 20mg/24 hrs ( all routes)

Switch to IV midazolam only if necessary once total max dose is reached.

Adult > 70 yrs or frail, dementia patients

• 2.5mg

Repeat as necessary every 15 mins to a total max dose 10mg/24 hrs ( all routes)

Switch to IV midazolam only if necessary once total max dose is reached.

Paediatric 6 - 16 yrs
0.2 mg/kg (max bolus 5mg)

Repeat as necessary every 30 mins to a total max dose 10mg/24 hrs ( all routes)

Question 9

** Droperidol**
Side effects

Answer 9

• Extrapyramidal effects / Dyskinesia
• Hypotension