Myofibre Types Flashcards

1
Q

What are the 3 Myofibre Types?
What metabolic pathways do you think each fibre relys on?

A
  1. Type I – slow oxidative (SO) - Aerobic
  2. Type IIa–fast oxidative glycolytic (FOG)-Anaerobic + Glycolosis
  3. Type IIx – fast glycolytic (FG)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are characteristics of Type I Fibres – Slow Oxidative?

6

A
  • Smallest diameter
  • High capacity for ATP production via OXPHOS
  • High capillarization – for more oxygen transport
  • High mitochondrial density – where OXPHOS takes place
  • Least powerful but greatest fatigue resistance (endurance fibres)
  • Speed of contraction (slow-twitch)

High myoglobin content gives more red colour (darker)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are characteristics of Type IIa Fibres – Fast Oxidative Glycolytic?

A
  • Intermediate diameter
  • Moderately powerful and moderate oxidative capacity
  • Moderate capillarization
  • Moderate-high mitochondrial density
  • Moderately susceptible to fatigue
  • Fast speed of contraction (fast-twitch
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are characteristics of Type IIx Fibres – Fast Glycolytic?

A
  • Largest diameter
  • Most powerful but low oxidative capacity
  • Low capillarization
  • Low mitochondrial density
  • Low fatigue resistance
  • Fast speed of contraction (fast-twitch)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Why does the size of a muscle fiber influence its force generating capacity?

A

Bigger muscle fibers have more sacromeres which allow for a larger contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How do we determine someone’s fibre type distribution?

A

Step 1: Muscle Biopsy (Vastus Lateralis)
- Freeze skin and fascia, cut and sunction small piece of muscle

Step 2: Tissue Sectioning
- use a tiny deli slicer? to cut off thin slice of muscle

Step 3: Tissue Staining
- choose proteins that only exist in a certain muscle fiber

Step 4: Analysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How many fibre types does one Motor Unit have?

A

Motor units contain only one fibre type

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the order of motor unit recruitment?

A

Motor unit recruitment goes from smallest to largest (low to high recruitment threshold)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Motor Unit function depends on size.
How do smaller and larger MU’s differ in function?

A
  • Small MU = muscles for fine movements
  • Large MU = muscle for gross/powerful movements
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How does Fibre Type Distribution differ?

A
  • No muscle has a single fibre type
  • Fibre type distribution (% of each fibre type found in that muscle) dictates muscle function
  • Largely determined by genetics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Thinking about the function of each of these muscles/muscle groups and estimate their fibre type distribution:
1. Postural Muscles of the back
2. Diaphragm
3. Muscles of the Arm
4. Muscles of the Leg

A
  1. Slow-Oxidative - always active, fatigue resistent
  2. Slow-Oxidative - also always active
  3. Mixture
  4. FOG
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the relationship between Fibre Type and Athletic Performance?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is Fatigue?

A

The decline in tension-generating capacity of the muscle.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does fatigue lead to?

A
  • Reduced shortening velocities and rate of relaxation
  • Onset and rate of development depends on
  • Active myofibre type
  • Intensity/duration of contractile activity
  • Fitness status of the individual
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tension Fatigue Graph

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How would an individual fatigue in this situation?

A
  • Rapid fatigue but quick recovery
  • Blood flow may cease to muscles due to blood vessel contraction (heavy weights)
17
Q

How would an individual fatigue in this situation?

A
  • Slower fatigue development and slower recovery
  • Cyclical periods of contraction and relaxation)
18
Q

What is Peripheral Fatigue?

A
  • Due to factors distal of the NMJ
  • Results from accumulation of metabolic by-products
  • Greater in myofibres with greater glycolytic capacity
19
Q

What is Central Fatigue (Central Command Fatigue)?

A
  • Due to factors proximal to the NMJ
  • Results from changes within the nervous system
  • Decreased motor neuron output
20
Q

What causes peripheral fatigue?

A

Metabolic byproducts of anaerobic glycolysis:

21
Q

What metabolic changes occure with Peripheral Fatigue?

A

Effects of Metabolic Changes:
1. Reduced Ca 2+ release, reuptake and storage by SR
2. Reduced sensitivity of thin filaments proteins to Ca 2+
3. Directly inhibit the binding/power-stroke motion of cross-bridges

22
Q

How does Peripheral Fatigue hinder us during Long-Duration Exercise?

A
  1. Leaky SR Ca 2+ channels -> persistently high cytosolic [Ca 2+] -> protease activity -> contractile protein degradation
  2. Depletion of fuel substrates:
  • ATP
  • Muscle glycogen
  • Blood glucose
  • Dehydration
23
Q

Weighlifting relies on anaerobic metabolism. Why then, does restricting blood flow lead to faster fatigue development?

A

need to get oxygen but also get rid of byproducts which cause fatigue.

24
Q

What about Central Command Fatigue?

A
  • The muscles are not fatigued by the individual stops exercising
  • Performance also depends on the mental ability to initiate central commands during periods of increasingly distressful sensations

We need more research!!

25
Q

Relative Role of Neural and Muscle Tissue Adaptation to Training

A