Mycoplasma pneumonia

Question 1

Etiology

Answer 1

Mycoplasma hypopneumoniae

Question 2

Pathogenesis

Answer 2

• Colonizes airways
• Inflammatory response
• Decreased mucociliary clearance

Question 3

Secondary infections with ____ and ____, and other pathogens are common.

Answer 3

• Pasteurella multocida*
• Streptococcus suis*

Question 4

Is uncomplicated mycoplasma infection mild?

Answer 4

Used to be mild. However, today we can have minimally complicated mycoplasma (not a lot of co-infection), and still see severe clinical signs. This is may be due to doing a good job of elimination of infectious diseases in the industry as a whole. So end up with healthy pigs with non-specific immune stimulation. When Mycoplasma gets introduced, then those healthy, naive pigs, suffer more than a pig that has been exposed to more pathogens.

Question 5

Mycoplasma infection is a major contributer to this disease complex:

Answer 5

Porcine Respiratory Disease Complex (PRDC)

Question 6

Majority of mycoplasma infections are complicated or uncomplicated?

Answer 6

Complicated

Question 7

Clinical signs

Answer 7

• Around the airways - more in the parenchyma of the lungs vs inside the airways: intersitial or peribronchiolar inflammatory response
  
  • Chronic, non-productive cough in grow/finish pigs (because nothing to cough up - nothing in airway)
  • Cough induced by exercise
• Minimal febrile response
• Minimal depression and anorexia
• Modest suppression of growth rates and feed efficiency

Question 8

Lesions of mycoplasma pneumonia include ____ lobar consolidation and ______ lymphoid hyperplasia.

Answer 8

• anterioventral lobar consolidation
• Peribronchiolar lymphoid hyperplasia

Question 9

The cough in Mycoplasma pneumonia is ______ (spontaneous or induced).

Answer 9

Induced!

Question 10

Diagnosis - culture is possible, but difficult becuase?

Answer 10

Mycoplasma hard to culture- easility overgrown by other bacteria.

Question 11

Which diagnostic tool may be useful for population profiling?

Answer 11

Serology - looking at when population is seroconverting

Question 12

Can you use PCR to diagnose?

Answer 12

Yes

Question 13

Examples of antimicrobials for treatment in feed or water:

Answer 13

• Lincomycin
• Tetracyclines
• Tylosin
• Tiamulin

Question 14

Control for M. pneumonia:

Answer 14

• Vaccination
• All-in, all-out
• Segregated early weaning - may eliminate
• Environmental management

Question 15

Herd elimination may be possible with partial depopulation of ____ to ____ pigs and medication of _____ swine.

Answer 15

• wean to finish
• breeding swine