Gastrointestinal Diseases in Neonates Flashcards
Etiology of Colibacillosis
E. coli
Collibacillosis is a common cause of diarrhea in pigs less than a _____ of age.
week
In colibacillosis, pathogenic strains adhere to the intestines by means of _____
Fimbria (pili)
Fimbrial antigens associated with Colibacillosis:
F4 (K88), F5 (K99), F6 (987P), F18, and F41
With Colibacillosis - the presence of receptors on the pigs enterocytes for the _____ fimbria are genetically controlled.
K88
In Colibacillosis, pathogenic strains produce ______ which cause secretion of fluid.
Enterotoxins
Enterotoxins are classified as heat _____ (LT) or heat _____ (STa, STb).
labile, stable
Enterotoxins cause hypersecretion of: ____, ____ and ______ into the gut lumen.
water, bicarbonate, and sodium
Enterotoxin will result in diarrhea, dehydration, _____ (acidosis or alkalosis), and _____ (hypokalemia or hyperkalemia)
acidosis, hyperkalemia
On post-mortem examination in a pig infected with Colibacillosis, should you see chyle going through mesentery?
Yes - because E. coli does not cuase malabsorptive diarrhea.
Treatment and control of Colibacillosis includes antibiotics, but what can we do the sow prefarrowing to protect neonates?
Stimulate immunity of the sow by vaccinating pre-farrowing, so that she will have anti-K88 anitbody in the colustrum - passing it to the neonate.
Etiology of Transmissible Gastroenteritis (TGE)
Coronavirus
While TGE causes diarrhea like collibacillosus, what other clinical sign is common with TGE infection, but not E. coli?
Vomiting
What kind of diarrhea does TGE produce?
Malabsorptive
TGE virus destroys the lining of the small intestine, leading to ____ _____.
Villus atrophy
Severity of TGE varies with the herd immunity. Please explain.
In a naive herd, where sows were never exposed to the virus, they cannot pass on antibodies to the virus in their colustrum to neonates. The mortality rate is very high in neonates from a naive herd. If the sows have been exposed however, neonates will benefit from passive immunity and mortality will decrease.
What can you do to control TGE in a naive herd?
Sacrifice a sick neonate, make a slurry of it’s intestines rich with virus, and feed to the sow’s during gestation, preferentially 2 or weeks prior to farrowing.
Porcine Epidemic Diarrhea (PED) had not been reported in the US prior to May, _____.
2013
PED causes high morbidity and high mortality in young pigs. It resembles ____ in clinical presentation, but negative to ____ diagnostic tests. And therefore, determined to be PEDV.
Resembles TGE, negative to TGEV diagnostic tests
Etiology of Porcine Epidemic Diarrhea (PED)
Coronavirus (similar but distinct from TGEV)
The clinical signs of PED include diarrhea and vomiting, and in acute outbreaks, what age of swine get severe diarrhea? What age will result in high mortality?
Severe diarrhea in all ages of swine; high mortality in preweaned piglets
What is the most common rought of transmission in PED?
Fecal-oral transmission
Infected pigs shed PED virus for how longs?
3-4 weeks