Muscle Relaxants

Question 1

Succinylcholine

Answer 1

depolarizing agent

react with nicotinic receptor and stays depolarized because it doesn’t get metabolized at synapse (Flaccid Paralysis)

very short duration of action and rapidly broken down

repolarization can occur but desensitized and cannot be easily depolarized again (phase 2 block)

Causes Arrhythmias + increased IOP

Question 2

Cisatracurium

Answer 2

non-depolarizing agent

competes with Ach for binding site and enters to block ion channel at high doses

less likely to produce toxic metabolite and most commonly used in clinic

Hypotension and Ganglionic Blockade

Question 3

Rocuronium and Vecuronium

Answer 3

non-depolarizing agent

competes with Ach for binding site and enters to block ion channel at high doses

highly dependent on liver metabolism and intermediate-acting

Question 4

Centrally Acting Spasmolytics

Answer 4

decrease muscle spasms and muscle tone

CNS depressants that interrupt neuronal communication leading to sedation and alteration in pain perception

Question 5

Baclofen

Answer 5

CAS

Gaba Receptor + inhibits spinal reflexes

Question 6

Carisoprodol

Answer 6

interrupts neuronal communication

CAS

Question 7

Cyclobenzaprine

Answer 7

CAS

5HT/NE receptor transmission

Question 8

Tizanidine

Answer 8

Alpha 2 Receptor

CAS

Question 9

Gabapentin

Answer 9

CAS

MOA: binds to carrier protein at unique receptor to elevate GABA levels

Tx: epilepsy in adults and children over 3 years old + pain + tremors + migraines

Question 10

Dantrolene

Answer 10

direct-acting muscle relaxant

MOA: blocks calcium channel in SR and decreases CA intracellularly which will decrease skeletal muscle strength by interfering with coupling in muscle fibers

less AE bc works DIRECTLY