Alzheimer's Disease

Question 1

Alzheimer’s Disease

Answer 1

neocortex damage and buildup of amyloid proteins in brain leading to plaques that decrease Ach / Glutamate

Question 2

Glutamate (MSG)

Answer 2

memory and learning

AMPA/Kainate R: binding leads to opening and depolarization

NMDA R: MG bound to it - needs depolarization for the magnesium to unbind and channel opens for calcium influx (DAMAGE)

Question 3

Cholinesterase Inhibitor (indirect intermediate)

Answer 3

Donezepil, Rivastigmine, Galantamine

Anorexia, Tremor, N/D, Bradycardia, Myalgia

Question 4

Glutaminergic Antagonist

Answer 4

binds to NMDA R and inhibits calcium influx

Memantine

Confusion, anxiety, chills, cough, dry mouth

LESS TOXIC THAN INDIRECT