Arrhythmia + Angina

Question 1

Disopyramide

Answer 1

Class 1a Sodium Channel Blocker

Binds to sodium + potassium channels and inhibits K+ efflux to slow conduction of phase 0 and slow repolarization of phase 3 which increases AP/RP duration

Question 2

Quinidine

Answer 2

Class 1a Sodium Channel Blocker

Binds to sodium + potassium channels and inhibits K+ efflux to slow conduction of phase 0 and slow repolarization of phase 3 which increases AP/RP duration

Question 3

Procainamide

Answer 3

Class 1a Sodium Channel Blocker

Binds to sodium + potassium channels and inhibits K+ efflux to slow conduction of phase 0 and slow repolarization of phase 3 which increases AP/RP duration

Question 4

Lidocaine

Answer 4

Class 1b Sodium Channel Blocker

Bind only to sodium channel but increases K+ efflux
which slows conduction of phase 0 and decreases AP/RP duration

Question 5

Mexiletine

Answer 5

Class 1b Sodium Channel Blocker

Bind only to sodium channel but increases K+ efflux
which slows conduction of phase 0 and decreases AP/RP duration

Question 6

Tocainide

Answer 6

Class 1b Sodium Channel Blocker

Bind only to sodium channel but increases K+ efflux
which slows conduction of phase 0 and decreases AP/RP duration

Question 7

Flecainide

Answer 7

Class 1c Sodium Channel Blocker

Binds to both sodium and potassium channels but no effect on potassium channels

Question 8

Propafenone

Answer 8

Class 1c Sodium Channel Blocker

Binds to both sodium and potassium channels but no effect on potassium channels

Question 9

Class 2: Beta Blockers

Answer 9

depress automaticity of SA node, prolong conduction of AV node, and decrease contractility + HR

Question 10

Amiodarone

Answer 10

Class 3: Potassium Channel Blockers that inhibit K+ efflux which prolong AP/RP duration

Question 11

Dronedarone

Answer 11

Class 3: Potassium Channel Blockers that inhibit K+ efflux which prolong AP/RP duration

Question 12

Sotalol

Answer 12

Class 3: Potassium Channel Blockers that inhibit K+ efflux which prolong AP/RP duration

Question 13

Ibutilide

Answer 13

Class 3: Potassium Channel Blockers that inhibit K+ efflux which prolong AP/RP duration

Question 14

Dofetilide

Answer 14

Class 3: Potassium Channel Blockers that inhibit K+ efflux which prolong AP/RP duration

Question 15

Diltiazem + Verapamil

Answer 15

Class 4: Calcium Channel Blockers

Arrhythmia Treatment

Question 16

Adenosine

Answer 16

nucleoside that activates K+ inward and inhibits calcium channel

Question 17

nitroglycerin

Answer 17

organic nitrate - vasodilator for angina

Question 18

What drugs are used for effort-induced (Stable) angina?

Answer 18

beta blockers (long-term) + rest/nitroglycerin

Question 19

What drugs are used for chronic angina?

Answer 19

sodium channel blockers

Question 20

What are the drug categories that are used for angina?

Answer 20

Organic Nitrates (VD), BB, Calcium Channel Blockers (Di + Non-Di), Sodium Channel Blockers, Type 5 Phosphodiesterase Inhibitors

Question 21

Sildenafil

Answer 21

Type 5 phosphodiesterase Inhibitor

potentiates the vasodilative effect of Ach

Question 22

Tadalafil

Answer 22

Type 5 Phosphodiesterase Inhibitor

potentiates the vasodilative effect of Ach

Question 23

Vardenafil

Answer 23

Type 5 Phosphodiesterase Inhibitor

potentiates the vasodilative effect of Ach