Blood Drugs + Hyperlipidemia

Question 1

Aspirin

Answer 1

Platelet Inhibitors

Inhibit Cox-1 to inhibit thromboxane A2 which inhibits clot formation

Question 2

Ticlopidine

Answer 2

Platelet Inhibitor

ADP Receptor Blocker which prevents expression of fibrinogen GPR

Question 3

Prasugrel

Answer 3

Platelet Inhibitor

ADP Receptor Blocker which prevents expression of fibrinogen GPR

Question 4

Clopidogrel

Answer 4

Platelet Inhibitor

ADP Receptor Blocker which prevents expression of fibrinogen GPR

Question 5

Ticagrelor

Answer 5

Platelet Inhibitor

ADP Receptor Blocker which prevents expression of fibrinogen GPR

Question 6

Abciximab

Answer 6

Platelet Inhibitor

GPR Blocker - directly inhibits fibrinogen from binding

Question 7

Tirofiban

Answer 7

Platelet Inhibitor

GPR Blocker - directly inhibits fibrinogen from binding

Question 8

Eptifibatide

Answer 8

Platelet Inhibitor

GPR Blocker - directly inhibits fibrinogen from binding

Question 9

Argatroban

Answer 9

Anticoagulant

Direct Thrombin Inhibitor

Question 10

Bivalirudin

Answer 10

Anticoagulant

Direct Thrombin Inhibitor

Question 11

Lepirudin

Answer 11

Anticoagulant

Direct Thrombin Inhibitor

Question 12

Desirudin

Answer 12

Anticoagulant

Direct Thrombin Inhibitor

Question 13

Dabigatran

Answer 13

Anticoagulant

Direct Thrombin Inhibitor

Question 14

Apixaban

Answer 14

Anticoagulant

Factor Xa Inhibitor

Question 15

Fondaparinux

Answer 15

Anticoagulant

Factor Xa Inhibitor

Question 16

Rivaroxaban

Answer 16

Anticoagulant

Factor Xa Inhibitor

Question 17

-PARIN Drugs

Answer 17

LMWH

Bind to antithrombin III and inactivate Factor Xa

Question 18

Heparin

Answer 18

Binds to antithrombin III and increases its activity which inactivates thrombin and Factor Xa

Question 19

Warfarin

Answer 19

Inhibits vitamin K epoxide reductase which decreases vitamin K which will decrease coagulation factors

Question 20

Urokinase

Answer 20

Thrombolytic Agent

Produced by kidney and cleaves the A-V bond in plasminogen to form plasmin

Question 21

Streptokinase

Answer 21

Thrombolytic Agent

Forms active complex with plasminogen and catalyzes degradation of fibrinogen etc

Question 22

Alteplase

Answer 22

Thrombolytic Agent

Activates plasminogen bound to fibrin in a thrombus

Question 23

Retaplase

Answer 23

Thrombolytic Agent

Question 24

Tenecteplase

Answer 24

Thrombolytic Agent

Binds to fibrin and converts plasminogen to plasmin

Question 25

Aminocaproic Acid

Answer 25

inhibit plasminogen from activating | Treats bleeding

Question 26

Protamine

Answer 26

heparin antagonist

Question 27

Vitamin K

Answer 27

antagonizes warfarin

Question 28

-STATIN drugs

Answer 28

HMG CoA Reductase Inhibitor Decrease LDL levels by A LOT contraindicated in teens, children, pregnancy, lactation

Question 29

Niacin

Answer 29

inhibits VLDL excretion which lowers LDL but mainly increases HDL

Question 30

What are the AE of Niacin?

Answer 30

flushing, warmth, abdominal pain, nausea, and hyperuricemia

Question 31

Colestipol

Answer 31

Bile Acid Sequesters | Bind to bile salts so that liver must convert cholesterol to bile (decreases LDL)

Question 32

Colesevelam

Answer 32

Bile Acid Sequesters | Bind to bile salts so that liver must convert cholesterol to bile (decreases LDL)

Question 33

Cholestyramine

Answer 33

Bile Acid Sequesters | Bind to bile salts so that liver must convert cholesterol to bile (decreases LDL)

Question 34

Gemfibrozil

Answer 34

Fibrates Increase expression of lipoprotein lipase and increase oxidation of FA (TG) in livers (Decrease TG)

Question 35

Fenofibrate

Answer 35

Fibrates Increase expression of lipoprotein lipase and increase oxidation of FA (TG) in livers (Decrease TG)

Question 36

Ezetimibe

Answer 36

Cholesterol Absorption Inhibitor | mild effects

Question 37

What are the contraindications for HMG Coa Reductase Inhibitors

Answer 37

pregnancy, lactation, child-teens

Question 38

What are the effects of statin

Answer 38

DECREASE LDL levels plaque stabilization, increase blood sugar levels, increase warfarin levels, improve coronary endothelial function and inhibit platelet thrombus

Question 39

What are the adverse effects and contraindications for Fibrates

Answer 39

Contraindicated in patients with kidney or liver dysfunction or history of gallbladder disease AE: GI disturbances, gallstones, inflammation of voluntary muscle and compete with warfarin

Question 40

What are the contraindications for ezetimibe

Answer 40

contraindicated in patients with liver (hepatic) dysfunction

Question 41

What are the side effects of Niacin

Answer 41

flush and warmth, nausea and abdominal pain and hyperuricemia