Blood Drugs + Hyperlipidemia Flashcards
Aspirin
Platelet Inhibitors
Inhibit Cox-1 to inhibit thromboxane A2 which inhibits clot formation
Ticlopidine
Platelet Inhibitor
ADP Receptor Blocker which prevents expression of fibrinogen GPR
Prasugrel
Platelet Inhibitor
ADP Receptor Blocker which prevents expression of fibrinogen GPR
Clopidogrel
Platelet Inhibitor
ADP Receptor Blocker which prevents expression of fibrinogen GPR
Ticagrelor
Platelet Inhibitor
ADP Receptor Blocker which prevents expression of fibrinogen GPR
Abciximab
Platelet Inhibitor
GPR Blocker - directly inhibits fibrinogen from binding
Tirofiban
Platelet Inhibitor
GPR Blocker - directly inhibits fibrinogen from binding
Eptifibatide
Platelet Inhibitor
GPR Blocker - directly inhibits fibrinogen from binding
Argatroban
Anticoagulant
Direct Thrombin Inhibitor
Bivalirudin
Anticoagulant
Direct Thrombin Inhibitor
Lepirudin
Anticoagulant
Direct Thrombin Inhibitor
Desirudin
Anticoagulant
Direct Thrombin Inhibitor
Dabigatran
Anticoagulant
Direct Thrombin Inhibitor
Apixaban
Anticoagulant
Factor Xa Inhibitor
Fondaparinux
Anticoagulant
Factor Xa Inhibitor
Rivaroxaban
Anticoagulant
Factor Xa Inhibitor
-PARIN Drugs
LMWH
Bind to antithrombin III and inactivate Factor Xa
Heparin
Binds to antithrombin III and increases its activity which inactivates thrombin and Factor Xa
Warfarin
Inhibits vitamin K epoxide reductase which decreases vitamin K which will decrease coagulation factors
Urokinase
Thrombolytic Agent
Produced by kidney and cleaves the A-V bond in plasminogen to form plasmin
Streptokinase
Thrombolytic Agent
Forms active complex with plasminogen and catalyzes degradation of fibrinogen etc
Alteplase
Thrombolytic Agent
Activates plasminogen bound to fibrin in a thrombus
Retaplase
Thrombolytic Agent
Tenecteplase
Thrombolytic Agent
Binds to fibrin and converts plasminogen to plasmin
Aminocaproic Acid
inhibit plasminogen from activating
Treats bleeding
Protamine
heparin antagonist
Vitamin K
antagonizes warfarin
-STATIN drugs
HMG CoA Reductase Inhibitor
Decrease LDL levels by A LOT
contraindicated in teens, children, pregnancy, lactation
Niacin
inhibits VLDL excretion which lowers LDL but mainly increases HDL
What are the AE of Niacin?
flushing, warmth, abdominal pain, nausea, and hyperuricemia
Colestipol
Bile Acid Sequesters
Bind to bile salts so that liver must convert cholesterol to bile (decreases LDL)
Colesevelam
Bile Acid Sequesters
Bind to bile salts so that liver must convert cholesterol to bile (decreases LDL)
Cholestyramine
Bile Acid Sequesters
Bind to bile salts so that liver must convert cholesterol to bile (decreases LDL)
Gemfibrozil
Fibrates
Increase expression of lipoprotein lipase and increase oxidation of FA (TG) in livers
(Decrease TG)
Fenofibrate
Fibrates
Increase expression of lipoprotein lipase and increase oxidation of FA (TG) in livers
(Decrease TG)
Ezetimibe
Cholesterol Absorption Inhibitor
mild effects
What are the contraindications for HMG Coa Reductase Inhibitors
pregnancy, lactation, child-teens
What are the effects of statin
DECREASE LDL levels
plaque stabilization, increase blood sugar levels, increase warfarin levels, improve coronary endothelial function and inhibit platelet thrombus
What are the adverse effects and contraindications for Fibrates
Contraindicated in patients with kidney or liver dysfunction or history of gallbladder disease
AE: GI disturbances, gallstones, inflammation of voluntary muscle and compete with warfarin
What are the contraindications for ezetimibe
contraindicated in patients with liver (hepatic) dysfunction
What are the side effects of Niacin
flush and warmth, nausea and abdominal pain and hyperuricemia
