Muscle Physiology ML:3 Flashcards
Steps of ECC coupling
-AP propagated along muscle cell membrane into the T tubules
-the voltage gates DHP receptor tugs on the RYRS which releases calcium into the cisterane
-the release of calcium increases the cyotosloic levels of calcium
-calcium then binds to troponiin and removes thr blocking actin of tropomyosin
-XBs occur
Calcium rises in the sarcoplasm which causes
cross birdge binds to actin
myosin extends the energy that was in the head causes
crossbridge moves “powerstroke”
Once atp binds and the cross bridge detaches ATP splits into ADP and Pi
hydrolysis of ATP energies cross bridge ATP
Symbols XB binds to actin
( A x M x ADP x Pi)
Symbols cross bridge moves powerstroke
(AxM)
Symbols ATP binds to myosin causes crossbridge to detach
(A + M x ATP)
Symbols hydrolysis of ATP energizes cross bridge
(A + M x ADP x Pi)