Mini Lesson Flashcards
Osteoblast
coverts cartilage to bone
Bone Growth Order (top-down)
-top of epiphyseal growth plate
-Epiphyseal growth plate
–just above the shaft you have cells undergo hypertrophy
-above that you have cells undergoing hyperplasia which is cell division
-shaft containing osteoblasts
Environmental factors that influence growth
adequate nutriton
freedom from chronic illness/disease
freedome from chronic stress
sleep
Testerone during puberty
stimulates GH and IGF-1 secretions prolonged exposure stimulates GH and IGF-1 secretions
Cortisol
exerts antigorwth effects such at catabolism, decalificaion of bone, inhibits GH and IGF-1 secretion
High GH and low cortisol
growth
HIGH GH and HIGH CORTSIOL
fuel mobilization, no growth
What is the most common cause of excess growth hormone
hypersecreting tumor of AP
Acromegaly
too much GH after epiphyseal plates close
Gigantism
too much GH before epiphyseal plates close
GH stimulates growth by
stimulating cell differentiation and dividison
-stimulation of protein synthesis
stimulating IGF-1
GH metabolic effects include
mobilize glucose for energy
mobilize fatty acids for energy
IGF-1 promotes growth by
stimulating cell division and protein synthesis