Muscle Paralytics and relaxants Flashcards
atracurium MOA
competes with Ach at the neuromuscular end plate
atracurium effect
inhibits muscle contraction
atracurium adverse events
produces respiratory depression and paralysis, no analgesis
atracurium contraindications
dont administer without ventilation, will be antagonized by ACHases dont give with amnoglycosides because of potentiated NMB
cisatracurium and pancuronium MOA
competes with ACh at the neuromuscular end plate
cisatracurium and pancuronium effect
used to inhibit muscle contractions
cisatracurium and pnacuronium adverse events
produces respiratory depression and paralysis, no analgesia
succinylcholine MOA
nibds to receptor, depolarizes it, stays and continues to block it
succinylcholine effect
not used for anything
succinylcholine advverse effects
death
diazapam MOA
activates GABA receptors, increasing Cl conductance causing hyperpolarization
diazapam adverse events
sedation, d-ataxia, anorexia, fatal hepatic necrosis; withdrawal
diazepam efect
anticonvulsant
midazolam MOA
activates GABA receptors increasing CL conductance -> hyperpolarization; water soluble; not like diazepam
midazolam effecr
anticonvulsant
midazolam adverse events
IV can cause cardaic depression; paradoxical excitment, withdrawal syndromes when discontinued
lorazepam MOA
activates GABA, receptors increasing Cl conductance-> yperpolarization
lorazepam effect
anticonvulsant
lorazepam adverse events
sedation, polyphagia, excitement, withdrawal syndrome
flumazenil moa
blocks action of benzodiazepines on GABA receptors
flumazenil effect
antidote
flumazenil adverse events
none reported
guafenesin MOA
stimulates vagal transmission for more viscous bronchial secretions (PO)
centrally acting muscle relaxant (IV)
guafenesin effect
expectorant; stimulates vagal transmission
guafenesin adverse events
thrombophlebitis from IV, hypotension, hemolysis
