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pharmacology > Muscle Paralytics and relaxants > Flashcards

Muscle Paralytics and relaxants Flashcards

1
Q

atracurium MOA

A

competes with Ach at the neuromuscular end plate

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2
Q

atracurium effect

A

inhibits muscle contraction

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3
Q

atracurium adverse events

A

produces respiratory depression and paralysis, no analgesis

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4
Q

atracurium contraindications

A

dont administer without ventilation, will be antagonized by ACHases dont give with amnoglycosides because of potentiated NMB

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5
Q

cisatracurium and pancuronium MOA

A

competes with ACh at the neuromuscular end plate

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6
Q

cisatracurium and pancuronium effect

A

used to inhibit muscle contractions

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7
Q

cisatracurium and pnacuronium adverse events

A

produces respiratory depression and paralysis, no analgesia

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8
Q

succinylcholine MOA

A

nibds to receptor, depolarizes it, stays and continues to block it

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9
Q

succinylcholine effect

A

not used for anything

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10
Q

succinylcholine advverse effects

A

death

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11
Q

diazapam MOA

A

activates GABA receptors, increasing Cl conductance causing hyperpolarization

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12
Q

diazapam adverse events

A

sedation, d-ataxia, anorexia, fatal hepatic necrosis; withdrawal

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13
Q

diazepam efect

A

anticonvulsant

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14
Q

midazolam MOA

A

activates GABA receptors increasing CL conductance -> hyperpolarization; water soluble; not like diazepam

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15
Q

midazolam effecr

A

anticonvulsant

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16
Q

midazolam adverse events

A

IV can cause cardaic depression; paradoxical excitment, withdrawal syndromes when discontinued

17
Q

lorazepam MOA

A

activates GABA, receptors increasing Cl conductance-> yperpolarization

18
Q

lorazepam effect

A

anticonvulsant

19
Q

lorazepam adverse events

A

sedation, polyphagia, excitement, withdrawal syndrome

20
Q

flumazenil moa

A

blocks action of benzodiazepines on GABA receptors

21
Q

flumazenil effect

A

antidote

22
Q

flumazenil adverse events

A

none reported

23
Q

guafenesin MOA

A

stimulates vagal transmission for more viscous bronchial secretions (PO)
centrally acting muscle relaxant (IV)

24
Q

guafenesin effect

A

expectorant; stimulates vagal transmission

25
Q

guafenesin adverse events

A

thrombophlebitis from IV, hypotension, hemolysis

pharmacology (11 decks)

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