Muscle contractile mechanisms Flashcards
- Outline anatomical differences between striated and smooth muscle, including organisation of actin, myosin, tropomyosin - Describe the different phases of the sliding filament hypothesis - Outline the process of rigor mortis, and how it relates to the sliding filament hypothesis
1
Q
What is each sarcomere composed of?
A
- Actin AND myosin, the proteins responsible for muscular contraction
1
Q
What is a sarcomere?
A
The basic contractile unit of muscle fibre
2
Q
What is the function of muscle?
A
- Provides movement to skeleton + hollow organs e.g. heart, blood vessels, GI tract
- Provides structure to skeleton and hollow organs when under pressure e.g. chambers of heart, circulation through vessels, bladder
3
Q
What are the 2 types of muscle?
A
- Striated- skeletal and cardiac muscle
- Smooth - blood vessels, GI tract, internal organs bar heart
4
Q
What 2 proteins are essential for contraction of both types of muscle?
A
- Actin
- Myosin
5
Q
Describe skeletal muscle
A
- Voluntary
- Single, very long cylindrical, multinucleate cells with obvious striations (stripes)
6
Q
Describe cardiac muscle
A
- Involuntary
- Striated
- Branching chains of cells, uni or binucleate; less organised striations than skeletal
7
Q
Describe smooth muscle
A
- Involuntary
- Single, fusiform, uninucleate, NO striations
8
Q
Why are muscles termed striated or smooth?
A
- Due to the structure of the myosin or actin filaments
- Striated muscles are striated as the A and I bands are aligned
9
Q
What are voluntary contractions controlled by?
A
- Motor nerves
10
Q
What are involuntary contractions controlled by?
A
- ANS (autonomic nervous system)
11
Q
How is striated muscle organised?
Describe it in terms of the Z, A, I and H bands
A
- Unit of striation- sarcomere
- Z band- attachment sites for actin, separate each sarcomere
- Light or I band- non- superimposed length of actin,
- Dark or A band- entire length of myosin, and shows slight overlap of actin with myosin
- H band - only myosin component of sarcomere, middle of A band
12
Q
What happens to the striated sarcomere during contraction?
A
- Myosin length stays the same, but actin moves across myosin, so the contraction occurs due to the increased overlap, whereas when the muscle is released, there’s only a very small overlap
13
Q
How is smooth muscle organised?
A
- Myosin and actin filaments are disorganised interaction at dense bodies
- This disorganisation allows for a more 3D contraction e.g. in hollow organs
14
Q
What are the 2 types of actin?
A
- G actin
- F actin