Mucosal Immunology Flashcards
Write out the different types of mucosal surfaces? Main tracts?
Slide 3
Respiratory and gastrointestinal
Write out the distinctive features of mucosal immunity.
Slide 4
Largest cause of human deaths?
Mucosal infections
Size (SA) comparison of skin and mucosal surfaces?
mucosal surfaces much larger
Draw out the different layers of mucosae in the intestine, airways, esophagus.
Slide 6
Mucosal surfaces exposed to what?
external environment
Draw out differences between anatomy of small intestine and large intestine.
Slide 8
Write out table to intestinal epithelial cells and their major functions.
Slide 9
Review images slide 10.
What are mucins secreted by?
goblet cells
Functions of mucin?
make mucus sticky and provide a framework where molecules pf secreted IgA and defensins can attach
Review the important roles epithelial cells play in innate defense against pathogens.
Slide 11
What do epithelial cells allow the transport of?
antigens across the mucosal barriers
Draw out pathway of transport of antigens across epithelial cells.
Slide 12
Make a table of AMP families and their mechanism of action.
Slide 13
Draw out pathway of how IGA transport to the mucosal surfaces.
Slide 14
How do immunoglobulin G transport to the mucosal surfaces. (2 steps)
Slide 15
4 mucosal functions of immunoglobulins?
Slide 16
What is the epithelium overlying lymphoid tissues within the intestinal mucosa specialized for?
uptake of particulate antigens
Lymphocytes activated in mucosal tissues return to those tissue as ___________.
effector cells
As a baby gets older the bacterial diversity _________ and interindividual diversity ______________.
increases
decreases
Review slide 20.
Elimination of commensal bacteria allows for proliferation of _____________.
pathogenic bacteria
The hosts strategy to combat the infection caused due to ________________________________.
breach of gut mucosal surfaces
Understand two fate-specifying cytokine pathways.
Slide 21
Write out content on slide 21.
Draw out the innate and adaptive phases of the host response to E. coli
Slide 22
