Mucosal Immunology

Question 1

Write out the different types of mucosal surfaces? Main tracts?

Answer 1

Slide 3
Respiratory and gastrointestinal

Question 2

Write out the distinctive features of mucosal immunity.

Answer 2

Slide 4

Question 3

Largest cause of human deaths?

Answer 3

Mucosal infections

Question 4

Size (SA) comparison of skin and mucosal surfaces?

Answer 4

mucosal surfaces much larger

Question 5

Draw out the different layers of mucosae in the intestine, airways, esophagus.

Answer 5

Slide 6

Question 6

Mucosal surfaces exposed to what?

Answer 6

external environment

Question 7

Draw out differences between anatomy of small intestine and large intestine.

Answer 7

Slide 8

Question 8

Write out table to intestinal epithelial cells and their major functions.

Answer 8

Slide 9

Question 9

Review images slide 10.

Question 10

What are mucins secreted by?

Answer 10

goblet cells

Question 11

Functions of mucin?

Answer 11

make mucus sticky and provide a framework where molecules pf secreted IgA and defensins can attach

Question 12

Review the important roles epithelial cells play in innate defense against pathogens.

Answer 12

Slide 11

Question 13

What do epithelial cells allow the transport of?

Answer 13

antigens across the mucosal barriers

Question 14

Draw out pathway of transport of antigens across epithelial cells.

Answer 14

Slide 12

Question 15

Make a table of AMP families and their mechanism of action.

Answer 15

Slide 13

Question 16

Draw out pathway of how IGA transport to the mucosal surfaces.

Answer 16

Slide 14

Question 17

How do immunoglobulin G transport to the mucosal surfaces. (2 steps)

Answer 17

Slide 15

Question 18

4 mucosal functions of immunoglobulins?

Answer 18

Slide 16

Question 19

What is the epithelium overlying lymphoid tissues within the intestinal mucosa specialized for?

Answer 19

uptake of particulate antigens

Question 20

Lymphocytes activated in mucosal tissues return to those tissue as ___________.

Answer 20

effector cells

Question 21

As a baby gets older the bacterial diversity _________ and interindividual diversity ______________.

Answer 21

increases
decreases

Question 22

Review slide 20.

Question 23

Elimination of commensal bacteria allows for proliferation of _____________.

Answer 23

pathogenic bacteria

Question 24

The hosts strategy to combat the infection caused due to ________________________________.

Answer 24

breach of gut mucosal surfaces

Question 25

Understand two fate-specifying cytokine pathways.

Answer 25

Slide 21

Question 26

Write out content on slide 21.

Question 27

Draw out the innate and adaptive phases of the host response to E. coli

Answer 27

Slide 22