Mucosal Immunity Flashcards
Regulates intestinal epithelial cell positioning and differentiation
Wnt Signaling
Determines cell lineage specification in the intestine
Notch Signaling
Mucosal microbiota, outer mucus layer, inner mucus layer, paneth cells, and goblet cells are elements of
Mucosal immunity
Produce secreted gel-forming mucin glycoproteins and RELM-B
Goblet cells
Produce antimicrobial peptides, lectins, and cytokines
Paneth cells
A highly hydrated, viscous secretion with a complex macromolecular constituency
Mucus
The major contributors to mucin viscosity are
Polymeric mucin glycoproteins
Permeable to macromolecules, while serving as a barrier to undesirable elements
Mucin
What are the three types of intercellular junctions?
Tight junctions, adherens junctions, desmosomes
Transmembrane protein located at the lateral surface of epithelial cells
Tight junctions
What are two examples of tight junctions?
Claudins and occludins
What is an example of an adherens junction?
Cadherins
Chemotactic for neutrophilsm onocytes, mast cells, and T cells
Cathelicidins
Cathelicidins induce degranulation by
Mast cells
Alters transcriptional responses in macrophages
Cathelicidins
What are two antimicrobial peptides?
Cathelicidins and defensins
Microbicidal against bacteria, fungi, spirochetes, protozoa, and viruses
Defensins
Defensins are present in
Neutrophils
Nonspecialized epithelial cells display remarkable
Plasticity
The secretory phenotype of mucosal epithelial lineage can be modified by
Infection or inflammation
Small mononuclear cells interspersed between epithelial cells
Intraepithelial lymphocytes
Intraepithelial lymphocytes are mostly
CD4(-)/CD8(-) or CD4(-)/CD8(+) cells
Intraepithelial lymphocytes express
NK cell receptors
Intraepithelial lymphocytes express integrin to interact with
E-cadherin on epithelial cells