Introduction to Pharmacology Flashcards
The study of how chemical agents, natural or synthetic, affect biological systems
Pharmacology
Can be hormones, neurotransmitters, or metabolites
Natural agents
May be developed to mimic an endogenous compound, compete with one, or alter how the endogenous compound interacts with its receptor
Synthetic agents
Receptors for monoamines such as epinephrine, seratonin, and dopamine are
G-protein coupled receptors
Another example of a G-protein coupled receptor is muscarinic receptors for
Acetylcholine
G-protein receptor antagonist that inhibits muscarinic receptors
Theophylline
Targeted by antagonists that are effective vasodilators used for angina, arrythmias, and hypertension
Ion Channels
An example of an ion channel is
Nicotinic receptors of ACh
Elevate Ach at synapse
-used for MG, glaucoma, AD, and dementia
Acetylcholinesterase inhibitors
Receptors for endogenous ligands such as EGF, PDGF, insulin, VEGF, and others
Receptor Tyrosine Kinases
Targeted by antibodies that block ligand binding drugs that modulate downstream effectors
Receptor Tyrosine Kinases
Typically small molecules with molecular weights of 100 to 1000
-act as agonists and antagonists
Drugs
Bind to target to elicit response
Agonist
Inhibits the ability of target to respond to agonist
Antagonist
The effect of a drug on the body
-the integration of molecular actions into an effect on the whole organism
Pharmacodynamics
