Innate Immunity III

Question 1

Plasmacytoid dendritic cells (pDCs) that have high amounts of TLR7 and 9 in their endosomes are particularly sensitive and specialized to respond to

Answer 1

Viruses

Question 2

In response to virus infection, the pDCs focus significant biosysnthetic capacity to producing

Answer 2

Type I IFNs

Question 3

These IFNs are secreted

Answer 3

Cytokines

Question 4

Can bind to neighboring cells (a paracrine effect) and induce the synthesis of a large number of proteins

Answer 4

Type I IFNs

Question 5

This leads these cells to become more resistant to virus infection by a broad range of

Answer 5

Viruses

Question 6

Basically, in target cells, the IFN establishes an

Answer 6

Anti-viral state

Question 7

After secretion, for some cell types, the IFN can feed back to the interferon receptor on the producing virus-infected cell (an autocrine reaction) and induce

Answer 7

Apoptosis

Question 8

Also stimulate most or all cell types of the innate and adaptive immune systems to undergo changes consistent with a stronger short-term and long-term antiviral response

Answer 8

Type I IFNs

Question 9

Type I IFNs increase presentation of

-for better presentation of viral antigens

Answer 9

Class I MHC/HLA

Question 10

Causes maturation of dendritic cells and MHC/HLA class II up-regulation for antigen presentation

Answer 10

Type I IFNs

Question 11

Type I IFNs lead to stimulation of B cell class switching for production of higher affinity and more effective

Answer 11

Antibodies