MSK Drugs

Question 1

Pyridostigmine

Neostigmine

Answer 1

Myasthenia gravis
Acetylcholinesterase inhibitors
Enhance activity at neuromuscular junction

Question 2

Atracurium
Cisatracurium
Mivacurium

Answer 2

Non-depolarising neuromuscular blocker
Surgical muscle relaxant
Competitive nAChr antagonists
Hypotension, flushing (histamine release)

Question 3

Pancuronium

Rocuronium

Answer 3

Non-depolarising neuromuscular blockers
Surgery
No histamine release

Question 4

Suxamethonium

Answer 4

Depolarising blocker for surgery muscle relaxation
Non-reversible
Muscle contractions at start- give after anaesthesia
Arrhythmia

Question 5

Baclofen

Answer 5

CNS acting muscle relaxant
GABAb receptor agonist gi linked
For M.S, MND muscle spasms
Drowsiness

Question 6

Tizanidine

Answer 6

CNS acting muscle relaxant
Adrenergic alpha 2 receptor agonist
Gi linked
Hypotension, arrhythmia

Question 7

Diazepam

Answer 7

Benzodiazepine
CNS muscle relaxant
GABAa receptor positive modulator = increase inhibition
Addictive

Question 8

Dantrolene

Answer 8

Peripheral acting muscle relaxant
Ryanodine receptor antagonist
Inhibits Ca release from store
Hepatoxicity, fatigue

Question 9

Osteoarthritis pathway

Answer 9

Paracetamol
Topical NSAID
capsaicin
Intra-articulate corticosteroid injection
Intra-articulate sodium hyaluronate injection

Question 10

Rheumatoid arthritis

Answer 10

DMARDs
Methotrexate 
Leflunomide- gi pain, hair loss, anaemia
Sulfalazine-for lower bowel inflammation 
Abatercept- biological DMARD

Question 11

Allopurinol

Answer 11

Gout