Immunopharmacology Flashcards
Immunosuppressive Cytokine modulators of TNF-alpha
Infliximab (only iv)
Etanercept
Infliximab
Inhibits TNF-alpha
Only iv
Used in crohns and rheumatoid arthritis
Side effects of TNF-alpha inhibitors
Respiratory tract infection
Uti
Abdo pain
Etanercept
TNF-alpha inhibitor
Used in rheumatoid arthritis
Adalimumab (humira)
Fully humainised monoclonal antibody
Inhibits lymphocyte proliferation
S/c injection 2 weekly
What is a brambell receptor FcRn
Receptor present in neonates future that allows antibodies to be absorbed from colostrum
Anti rejection immunosuppressants
Inhibit enzyme calcineurin so no IL-2 production= no Lymphocyte activation by T-helper cells
Ciclosporin
Tacrolimus
Sirolimus
Ciclosporin
Inhibits calcineurin (IL-2)
Prevents acute rejection
No bone marrow suppression
Nephrotoxic, hepatotoxic
Tacrolimus
Inhibits calcineurin production IL-2
Less adverse effects than ciclosporin
Sirolimus
Inhibits effects of IL-2
Low kidney toxicity
Methotrexate
Immunosuppressant
Inhibits bass synthesis by inhibiting dihydrofolate reductase
Cyclophosphamide
Immunosuppressant
Prevents DNA replication
Azathioprine
Immunosuppressant
Similar to guanine so gets incorporated in DNA
Theralizumab
Immunostimulation
For activation against cancer
CD28 superagonist = T cell activation
