Menopause Flashcards
1
Q
Menopause
A
Elevated FSH with no menstruation for over 1 year
2
Q
HRT
A
Estradiol- reduce symptoms and osteoporosis
Norethisterone- reduces endometrial hyperplasia
3
Q
Evorel conti
A
HRT
4
Q
HRT risks
A
Breast ca
Endometrial ca
Thrombosis
Stroke
5
Q
Bisphosphonates
A
Inhibit action of osteoclasts
Zolendronic acid
6
Q
Denosumab
A
RANKL inhibitor = inhibit osteoclast differentiation
7
Q
What does aromatase do?
A
In postmenopausal women oestrogen is derived from the metabolism of androgens by aromatase
8
Q
Aromatase inhibitors
Breast ca
A
Anastrozole, letrozole
Exemestrane
9
Q
Tamoxifen
A
Selective oestrogen receptor antagonist
Agonist in bone
Antagonist in breast
