Anti-parasitic

Question 1

Mebendazole

Answer 1

For thread worm (worms)

Starves nematode of glucose

Question 2

Metronidazole

Answer 2

Giardiasis- Gardia lamblida

Question 3

What is a tertian fever?

Answer 3

3 days fever then chills due to plasmodium life cycle

Malaria

Question 4

Why is malaria hard to treat?

Answer 4

Has a life cycle in the liver and the rbc

Question 5

Chloroquine

Answer 5

Malaria

Stops haem being polymerased so haem remains toxic

Question 6

Quinidine

Answer 6

Same as chloroquine but more lipid soluble
Stops haem polymerase
Arrhythmia, n&v, hypotension
IV

Question 7

Artemisinin

Answer 7

Sever plasmodium falciparum malaria
Free radical damage by haem activation
Take soon after

Question 8

Proguanil

Answer 8

Inhibits dihydrofolate reductase in malaria

Use as prophylaxis with chloroquine

Question 9

Atovaquone + proguanil

Answer 9

Blood and liver forms of p.falciparum
Targets mitochondria + enzyme
Prophylaxis- difficult to build resistance against it

Question 10

Doxycylcine

Answer 10

Use in chloroquine resistant areas of malaria

But use clindamycin for preg/child

Question 11

Primaquine

Answer 11

Treatment or prophylaxis
Causes G6PD deficiency- haemolytic anaemia
Renal failure
Use alongside artemisinin

Question 12

What can you use with primaquine to prevent G6PD deficiency

Answer 12

Artemisinin