Anti-fungal Drugs

Question 1

What do anti-fungal drugs target?

Answer 1

Ergosterol in fungal cell wall

Question 2

Amphotericin

Answer 2

Targets ergosterol = pore formation
IV
Cryptococcal meningitis
Side effects: fever, kidney failure, low mg,ca,k

Question 3

Flucytosine

Answer 3

Use alongside amphotericin to reduce side effects

Risk of bone marrow suppression

Question 4

Nystatin

Answer 4

Ergosterol wall pore formation
Topical use only
Use for thrush in mouth

Question 5

What effect do anti-fungals have on liver?

Answer 5

Liver inducers

Question 6

What does ‘azole’ indicate?

Answer 6

Inhibitors of ergosterol synthesis

Question 7

Clotrimazole

Answer 7

Canestan
Thrush
Topical

Question 8

Miconazole

Answer 8

Dactarin

Athletes foot

Question 9

Ketonazole

Answer 9

Liver toxicity if taken orally

Topical only

Question 10

Fluconazole

Answer 10

Oral/ IV

Second line cryptococcal meningitis

Question 11

Itraconazole

Answer 11

Broader spectrum
CNS
Aspergillus

Question 12

Voriconazole

Answer 12

Aspergillosis
Use in fluconazole resistant
Blurred vision

Question 13

Terbinafine

Answer 13

Lipid soluble so used for nail infections

Question 14

Caspofungin

Answer 14

Use for systemic infection in immune compromised

Aspergillus/candida IV