Antibiotics DNA Flashcards
1
Q
DNA base synthesis targets
A
Sulphonamides:
Inhibit production of folic acid in bacteria
Trimethoprim
Nitrofuratoin
2
Q
Trimethoprim
A
Water soluble
Broad spectrum aerobic gram pos + neg
GI upset, hyperkalaemia, rash
3
Q
Nitrofuratoin
A
Uti
Multiple methods of action = no resistance to it
Renal excretion unchanged = good for uti
4
Q
DNA unwinding
A
Quinolones
Ciprofloxacin (pseudomonas A)
Levofloxacin (pseudomonas/mrsa)
Moxifloxacin
5
Q
Ciprofloxacin
A
Pseudomonas A Aerobic gram negative Uti Severe GI Kept for 2nd/3rd line Arrhythmia, tendon rupture, seizure Interacts: theophylline, nsaid
6
Q
DNA strand breaks
A
Metronidazole Prodrug at target site Anaerobic only Avoid alcohol, warfarin Hypotension, headache
7
Q
RNA Polymerase inhibitor
A
Rifampicin
Stops transcription of dna to rna so stops protein synthesis
For TB
8
Q
Pyrazinamide
A
Anti-tb drug
Can be used with rifampicin
Stops protein/mRNA
