Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

LAST MINUTE! > MSK/Derm > Flashcards

MSK/Derm Flashcards

1
Q

SEE RYANS DECK FOR ANATOMY/NERVES

A

SEE RYANS DECK FOR ANATOMY/NERVES

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Things that shorten in muscle contraction

A

HIS:
H = just myosin
I = just actin
S = sarcomere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Type I muscle fibres

A

Slow twitch
red
ox-phos - mitochindria and myoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Ca+ channel on smooth muscle

A

L-type VG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

FGFR-3 constituitive activation effect:

A

INHIBITION of chondrocyte proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

defective bone resorption

A

Osteopetrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Defective bone mineralization

A

Osteomalacia/rickets (with high ALP)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

high ALP alone

A

Pagets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

High ALP with low Ca, low PO4, and high PTH

A

Osteomalacia/rickets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

causes of aseptic necrosis

A 
Alcoholism
Sickle/Storage (Gauchers)
Endo/exo steroids
Pancreatitis
Trauma
Idiopathic (legg-calve-Perthes)
Caissons
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Tumour@ epiphysis:

A

Giant cell:

  • benign - osteoclastoma
  • 20-40
  • soap bubbles
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tumour @ metaphysis:

A

Osteochondroma:

  • benign
  • males 65
  • via pagets, p53, Rb, infarcts, radiation
  • codman’s triangle/sunburt

Osteomyelitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Tumour @diaphysis

A

Ewing sarcoma:

  • malignant
  • males
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MCP involvement

A

RHEUMATOID ARTHRITIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Random causes of gout

A

Thiazies - compete for transporters
Von Geirkes - lactic acidosis, compete for transporters
leish nyhan or PRPP excess - overproduction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

pseudogout crystals

A

calcium PPi = chondrocalcinosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

pseudogout epidemiology

A

OA, hyperPTH, hemachomatosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Gonococcal artritis triad

A

STD:
synovitis
tenovitis
dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

ankylosing spondylitis associations

A

uveitis

aortic regurg

20
Q

Reiters epidemiology

A

chlamydia

GI: shigella, salmonella, yersinia, campylobacter, c. diff

21
Q

hypercoaguable with paradoxical increase in PTT

A

SLE

22
Q

Anti-PL syndrome Abs

A

lupus anticoagulant
anticardiolipin
anti-b2 glycoprotein

23
Q

FP tests with anti-PL syndrome

A

VDLR

long PTT

24
Q

increased CD4:CD8 ratio

A

Sarcoidosis

25
Q

Shaumann and asteroid bodies

A

sarcoidosis

26
Q

Polymyalgia rheumatica

A
  • pain and stiff shoulder and hip gurdles
  • fever, malaise, weight loss, ESR, CRP
  • women >50
  • associated with temporal arteritis
  • NO weakness, NO CK
27
Q

Fibromyalgia

A
  • widesread MSK pain with stiffness, paresthesias, poor sleep, fatigue
  • young women 20-50
  • rx = exercise, antidepressants, anticonvulsants
  • NO inflammation so no markers
28
Q

Polymyositis

A
  • symmetrical proximal muscle weakness (shoulders)
  • ENDOmysial inflammation
  • CD8
  • CK, ANA, anti-Jo, anti-SRP, anti-Mi-2
29
Q

Dermatomyositis

A
  • like polymyositis, BUT CD4 and PERImysial
  • malar rash, helicotrope (eyes), “shawl and face”, grottons papules, mechanic hands
  • increased risk of GU cancers
30
Q

proximal muscle weakness with autonomic shit

A

Lambert-Eaton

31
Q

MCCD scleroderma

A 
pulmonary sclerosis (pulm HTN)
[also renal, CV, GI sclerosis]
32
Q

cleft palate via

A

primary palate (intermaxillary segment) and secondary palates (maxillary prominences) fail to fuse
OR
if secondary palates fail to fuse together

[cleft lip = intermaxillary segment and maxilary prominences, but NOT the palate part)

33
Q

Inheritance of male-pattern baldness

A

polygenic inheritance with variable penetrance

34
Q

common peroneal nerve split functions

A

deep = anterior leg muscles (dorsiflex foot) and sensation between toes 1 and 2

superficial = lateral leg muscles = evert foot and sensation to most of foot dorsum

35
Q

parakaratosis

A

hyperkaratosis (increase SC thickness) with retention of nuclei

36
Q

acanthosis

A

stratum spinosum hyperplasia

37
Q

cholasma/melasma

A

hyperpigmentation of pregnancy/OCP

38
Q

intradermal vs junctional nevi

A 
intradermal = papule
junctional = macule
39
Q

ssss histo

A

Stratum granulosum keratinocyte attachments destroyed

40
Q

TEN histo

A

dermal-epidermal junction destroyed

41
Q

eosinophils in blistering disorder

A

bullous pemphigoid

42
Q

acanthosis nigracans associated with:

A 
hyperinsulinemia
visceral malignancies (gastric ACA)
43
Q

sawtooth lymphocyte infiltrate at dermal-epidermal junction

A

Lichen planus

44
Q

Basal cell CA

A

ulcerating with rolled boarders
telangectasias
pallisading nuclei

45
Q

SCC

A

sunlight, immunosuppression, irritation, arsenic
keratin pearls

actinic keratosis - precursor, rough, can horn
keratoacanthoma - variant that spontaneously regresses

46
Q

Melanoma

A

S-100

variants:

  • superficial spreading
  • nodular (bad)
  • lentigo malinga
  • acral lentiginous (no UV relation)

LAST MINUTE! (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions