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LAST MINUTE! > Immuno > Flashcards

Immuno Flashcards

1
Q

axillary nodes drain

A

all skin above diaphragm, breast, arm

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2
Q

superficial inguinal drains

A

all skin below umbilicus including lower anal canal and scrotum; except popliteal territory (post. calf + DL foot)

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3
Q

S’s in skine skies

A

s. pneumo
salmonella
GBS

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4
Q

PAMPs

A

bound by TLC in innate immunity i.e. by NK cells

ex: LPS, flagellin, ssRNA

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5
Q

TAP proteins

A

MHC-I

bring Ag from protasome to ER to get bound

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6
Q

Invariant chain

A

MHC-II

Blocks binding site in vesicle until fusion with PL

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7
Q

CD16

A

on NK cells, binds to Fc of bound IgG inducing ADCC

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8
Q

activate NK with:

A

IL-2, IL-12, IFN-a, IFN-b

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9
Q

activation of TH17

A

IL-6, TGF-b, STAT-3

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10
Q

activation of T-cells co-stim:

A

APC B7——CD28 T-cell (h or c)

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11
Q

activation of B-cells co-stim:

A

Th CD40L——–CD40R B-cell

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12
Q

cytokines inducting:

  • IgG
  • IgA
  • IgE
A
  • IgG = IL-4
  • IgA = IL-5, TGF-b
  • IgE = IL-4 + IL-13
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13
Q

inducer of APRs

A

IL-6

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14
Q

CRP functions:

A

opsonin
fixes complement
facilitates phagocytosis

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15
Q

Down regulated APRs:

A

albumin

transferrin (taken up by macro to hide Fe)

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16
Q

Inhibitors of complement

A

DAF (DC55) and CI-esterase inhibitor

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17
Q

anaphylaxis signals

A

via complement activation: C3a C4a C5a

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18
Q

Macrophage markers

A

CD14 - (aka TLR4) binds lipid A of LPS
CD40 - binds CD40L of Th
B7 - binds Th/Tc to activate them
Fc-R and C3b-R - phagocytosis

19
Q

NK markers

A

CD16 - ADCC by binding Fc of IgG

CD 56 - marker

20
Q

superantigens mechanism

A

crosslink TCR and MHC-II

thus can activate ANY t-cell

21
Q

HST resulting in systemic symptoms and vasculidities

A

Type III

22
Q

transfusion reactions:

A

to plasma proteins = allergic or anaphylactic (IGA defic.)
to HLA Ag and WBCs = febrile non-hemolytic
to RBCs = acute hemolytic

23
Q

anti-centromere

A

CREST

24
Q

polymyositis/dermatomyositis Abs

A

Anti-Jo
Anti-SRP
anti-Mi-2

25
Q

PBC ab

A

anti-mitochrondrial

26
Q

scleroderma abs

A

Anti-Scl-70

anti DNA topo-I

27
Q

anti-sm

A

autoimmune hepatitis

28
Q

anti-CCP

A

RA

29
Q

ASCA

A

Chrons

30
Q

No B-cell + no IGs vs. no plasma cells + no Igs

A

No B = BTK deficiency (Bruton’s agammaglobulinemia)

No plasma = combined variable immunodeficiency

31
Q

IL-12-R deficiency

A

systemic fungal and mycobacteria infections because macrophages releasing IL-12 does nothing

AR

32
Q

Job syndrome

A

hyper IgE - AD
STAT-3 mutation, no TH17, so PMN chemotaxis or IgE down regulation
Facies, cold abscesses, eczema, retained teeth

33
Q

low TRECs

A

SCID
also no thyme shadow, germinal centrism or T-cells
do NOT give live vaccines!
Get every type of infection

34
Q

immune defic. with high AFP

A

Ataxia telangectasia

low IgA, IgG, IgE

35
Q

immune defic. with thombocytopenia

A

W.A
triad = thrombocytopenia, eczema, recurrent infections
also autoimmune diseases and malignancies
via actin cytoskeleton problem
*low IgG and IgM
*high IgA and IgE

36
Q

high IgE

A

Job

W.A (also high IgA)

37
Q

delayed umbilical cord separation

A

LFA-1 (CD-18) defic.

LAD

38
Q

albanism + neuro

A

chediak higashi; LYST

pancytopenia

39
Q

Nitroblue tetrazolium dye test yellow

A

CGD

make granulomas because can’t kill them with res. burst

40
Q

graft thrombosis with ishcemia/necrosis

A

Hyperacute; preformed Abs

41
Q

graft vasculitis with dense intersitial lymphocyte infiltrate

A

acute; CD8

42
Q

proliferation of vascular SM with parenchymal atrophy and interstitial fibrosis; AS

A

chronic; CD4 (cytokines)

43
Q

post-graft jaundice, rash, diarrhea, HS_megally

A

GVHD

liver and BM transplants

LAST MINUTE! (15 decks)

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