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LAST MINUTE! > Micro - Viruses > Flashcards

Micro - Viruses Flashcards

1
Q

recombination vs. reassortment

A 
recomb = non-fragmented chromosomes (adenovirus)
reass = segmented genomes (influenza)
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2
Q

killed vaccine

A

Rabies
Injected influenza
Polio Salk (IM)
HepA

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3
Q

DNA viruses:

A

Hepadna, Herpes, Adeno, Parvo, Pox, Papilloma, Polyoma

Most are dsDNA and linear and icosahedral and replicate in nucleus and directly infectious

ssDNA = parvovirus
circular = papiloma, polyoma (JC + BK), hepadna (HBV)
complex = pox
replicate in cytosol = pox - carries an RNA pol
Not directly infectious = pox and HBV

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4
Q

RNA viruses:

A

Most ssRNA
- reoviridae is dsRNA (colti, rota)

\+ve:
retro
toga
calici
corona
picorna
flavi
hepe
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5
Q

Directly infectious

A 
all +ssRNA
all dsDNA (except pox and HBV)
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6
Q

Where do DNA viruses replicate

A

nucleus (except pox)

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7
Q

Where do RNA viruses replicate

A

cytosol (except influenza and retroviruses i.e. HIV)

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8
Q

naked =

A

DNA = PAPP
[papilloma, adeno, parvo, polyoma]

RNA = CPR HepE
[calici, picorna, reo, HepE]

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9
Q

Where do viruses get their envelopes

A

PM

[exception = herpes = nuclear membrane]

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10
Q

adenovirus s/s

A

febrile phayngitis
conjunctivitis
pneumonia
acute hemorrhagic cystitis

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11
Q

parvovirus s/s

A
  • fetus = hydrops fetalis
  • kids = fifth disease/erythema infectiosum/slap cheek (get lacy rash after)
  • kid with sickle = aplastic crisis
  • adults = pure red cell aplasia with RA-like symptoms
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12
Q

HPV strains

A

high risk = 16, 18, 31, 33

low risk = 1, 2, 6, 11

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13
Q

polyoma virus

A

JC - PML

BK - transplants

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14
Q

EBV infects B cells via

A

CD21

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15
Q

EBV vs CMV histo

A 
EBV = downey cells (reactive T-cells)
CMV = owl-eye
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16
Q

Segmented RNA viruses

A

BOAR

Reoviruses - colti and rota
Orthomyxoviruses - influenza
Arenaviruses - LCMV and lassa fever
Bunyaviruses -
- Arbociruses: california encephalitis, sandfly/rift valley fevers, crimran-congo hemorrhagic fever
- Non-arbo: Hantavirus (hemorrhagic fever and pneumonia)

17
Q

Non-segmented RNA viruses

A

Picorna - PERCH
Hepe
Calici - norwalk
Flavi - HCV, yellow fever, dengue, st. louis encephalitis, west nile
Toga - rubella, Eastern and Western equine
Retro - HIV, HTLV
Corona - corona
Paramyxo - Parainfluenza, RSV, measles, mumps
Rhabdo - rabies
Filo - Ebola/marburg
Delta - HDV

18
Q

All RNA viruses

A

ds: reo

+ss:
toga, retro, calici, corona, picorna, flavi, hepe

-ss:
ABPOFR = arena, bunya, paramyxo, orthomyxo, filo, rhabdo
*need to bring their own RNA-dependent RNA-pol

19
Q

Yellow fever s/s

A

Flavi; +; enveloped

high fever, black vomit, jundice
councilman bodies (viral injury of hepatocytes)
20
Q

F (fusion) protein

A

paramyxoviruses (parainfluenza, RSV, mumps, measles)
causes respiratory epithelial cells to fuse into multinucleated cells

Block with palivizumab to prevent RSV pneumonia in premature infants

21
Q

virus with pulsus paradoxus

A

croup (parainfluenza)

22
Q

Warthin-Finkeldey giant cells

A

fused lymphocytes in measles

23
Q

vitamin against virus

A

Vitamin A for measles

24
Q

rabies stuff

A

binds ACH-Rs
Negri bodies
purkinje cells of cerebellum and hippocampal neurons

25
Q

cells hit by ebola

A

endothelial, hepatocytes, phagocytes

26
Q

DNA pol with DNA and RNA dependent functions

A

HepB

27
Q

bad Hep for pregnant peope

A

HepE - fulminant liver failure

28
Q

marker during HepB window period

A

HBc-Ab
IgM = recent/acute
IgG = part or CHRONIC

29
Q

HBe =

A

infectivity

30
Q

HIV genes and products:

A

env = gp120 (binds CD4+) and gp41 (fusion and entry)
- binding needs co-R = CCR5 on macrophages or CXCR4 on T-cells
- gp120 crosses placenta .: FP in babies
pol = RT, aspartate protease, integrase
gag = capsid

31
Q

viruses that can make polyprotein product that then get cut up

A

RNA
+ss
linear
non-segmented

LAST MINUTE! (15 decks)

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