Micro - Viruses Flashcards
recombination vs. reassortment
recomb = non-fragmented chromosomes (adenovirus) reass = segmented genomes (influenza)
killed vaccine
Rabies
Injected influenza
Polio Salk (IM)
HepA
DNA viruses:
Hepadna, Herpes, Adeno, Parvo, Pox, Papilloma, Polyoma
Most are dsDNA and linear and icosahedral and replicate in nucleus and directly infectious
ssDNA = parvovirus
circular = papiloma, polyoma (JC + BK), hepadna (HBV)
complex = pox
replicate in cytosol = pox - carries an RNA pol
Not directly infectious = pox and HBV
RNA viruses:
Most ssRNA
- reoviridae is dsRNA (colti, rota)
\+ve: retro toga calici corona picorna flavi hepe
Directly infectious
all +ssRNA all dsDNA (except pox and HBV)
Where do DNA viruses replicate
nucleus (except pox)
Where do RNA viruses replicate
cytosol (except influenza and retroviruses i.e. HIV)
naked =
DNA = PAPP
[papilloma, adeno, parvo, polyoma]
RNA = CPR HepE
[calici, picorna, reo, HepE]
Where do viruses get their envelopes
PM
[exception = herpes = nuclear membrane]
adenovirus s/s
febrile phayngitis
conjunctivitis
pneumonia
acute hemorrhagic cystitis
parvovirus s/s
- fetus = hydrops fetalis
- kids = fifth disease/erythema infectiosum/slap cheek (get lacy rash after)
- kid with sickle = aplastic crisis
- adults = pure red cell aplasia with RA-like symptoms
HPV strains
high risk = 16, 18, 31, 33
low risk = 1, 2, 6, 11
polyoma virus
JC - PML
BK - transplants
EBV infects B cells via
CD21
EBV vs CMV histo
EBV = downey cells (reactive T-cells) CMV = owl-eye
Segmented RNA viruses
BOAR
Reoviruses - colti and rota
Orthomyxoviruses - influenza
Arenaviruses - LCMV and lassa fever
Bunyaviruses -
- Arbociruses: california encephalitis, sandfly/rift valley fevers, crimran-congo hemorrhagic fever
- Non-arbo: Hantavirus (hemorrhagic fever and pneumonia)
Non-segmented RNA viruses
Picorna - PERCH
Hepe
Calici - norwalk
Flavi - HCV, yellow fever, dengue, st. louis encephalitis, west nile
Toga - rubella, Eastern and Western equine
Retro - HIV, HTLV
Corona - corona
Paramyxo - Parainfluenza, RSV, measles, mumps
Rhabdo - rabies
Filo - Ebola/marburg
Delta - HDV
All RNA viruses
ds: reo
+ss:
toga, retro, calici, corona, picorna, flavi, hepe
-ss:
ABPOFR = arena, bunya, paramyxo, orthomyxo, filo, rhabdo
*need to bring their own RNA-dependent RNA-pol
Yellow fever s/s
Flavi; +; enveloped
high fever, black vomit, jundice councilman bodies (viral injury of hepatocytes)
F (fusion) protein
paramyxoviruses (parainfluenza, RSV, mumps, measles)
causes respiratory epithelial cells to fuse into multinucleated cells
Block with palivizumab to prevent RSV pneumonia in premature infants
virus with pulsus paradoxus
croup (parainfluenza)
Warthin-Finkeldey giant cells
fused lymphocytes in measles
vitamin against virus
Vitamin A for measles
rabies stuff
binds ACH-Rs
Negri bodies
purkinje cells of cerebellum and hippocampal neurons
