[MS] Allergy Flashcards
What is the function of Class I HLA antigens?
Present non-self (cancer/viruses) to CD-8+ cells
What is the function of Class II HLA antigens?
Found on macrophages to present antigens to CD-4+ cells
What is the inheritance pattern of the most common form of SCID?
X-linked (IL-2R-gamma)
What is a common radiographic finding for children with SCID?
Absence of the thymic shadow
What are the symptoms seen with the Omenn Syndrome-variant of SCID?
Severe Erythroderma Marked Eosinophilia Diarrhea Hepatosplenomegaly Failure to Thrive
What is the mnemonic to help remember Wiskott-Aldrich syndrome?
Eczema
X-Linked
Immunodeficiency
Thrombocytopenia (with small platelet size)
What are the characteristic findings of Ataxia-Telangiectasia?
Autosomal recessive Cerebellar ataxia Oculocutaneous telangiectasia Increased risk of cancer Elevated alpha-fetoprotein Sinopulmonary disease with bronchiectasis
What is the chromosomal abnormality of DiGeorge syndrome?
Deletion of 22q11.2
What are the clinical findings associated with DiGeorge syndrome?
Craniofacial anomalies (micrognathia, hypertelorism, shortened philtrum, low-set ears) Cardiac anomalies (tetrology of Fallot, VSD, transposition) Subclinical hypoparathyroidism
What is the genetic defenct found in Bruton’s Agammaglobulinemia?
Xq22 mutation
What is the most severe infection patients with Duncan syndrome could get?
EBV infection as it causes lymphoproliferative disease
What are the common clinical findings assocaited with type I leukocyte adhesion defect?
Delayed umbilical cord separation and cigarette paper scarring of the skin
What are the common clinical manifestations of Job’s syndrome (Hyper IgE)?
Eczema, delayed dental exfoliation, cold abscesses, and post-infectious pulmonary cysts
What are the common clinical findings of Chediak-Higashi syndrome?
Recurrent sinopulmonary infections, partial oculocutaneous albinism, and giant neutrophil granules
What future problem are deficiences of C1/C2/C4 associated with?
Rheumatologic problems such as SLE
