Morphologic markers Flashcards
1
Q
Neurofibrillary tangles
A
Alzheimer’s disease
2
Q
PsaMMoma bodies
A
Papillary thyroid CA
Serous cystadenoCA of ovaries
Meningioma
Mesothelioma
3
Q
Foam cells
A
Atherosclerosis
4
Q
Strawberry gallbladder
A
Cholesterolosis
5
Q
Bread-and-butter appearance
A
Fibrinous pericarditis
6
Q
Shaggy membrane of necrotic tissue (pseudomembrane)
A
Diphtheria
Esophageal carcinoma
Pseudomembranous colitis
7
Q
Langhan’s type of giant cells
A
PTB
8
Q
Foreign-body type of giant cells
A
Keloids
9
Q
Lines of Zahn
A
Antemortem thrombosis
10
Q
chicken fat
A
Postmortem thrombosis
11
Q
Libman-Sacks endocarditis (sterile)
A
SLE
12
Q
Virchow-Robin spaces
A
Gaucher disease
13
Q
Zebra bodies
A
Niemann-Pick disease
Mucopolysaccharidoses
14
Q
Balloon cells
A
Mucopolysaccharidoses
15
Q
Russell bodies Flame cells Mott cells Dutcher bodies Rouleaux formation
A
Multiple myeloma
16
Q
Reed-sternberg cells
A
Hodgkin’s lymphoma
17
Q
Starry sky pattern: nuclear remnants are phagocytosed by interspersed macrophages w/ abundant clear cytoplasm
A
Burkitt’s Lymphoma
18
Q
Cloverleaf or flower cells
A
Adult T-cell lymphoma
19
Q
Smudge cells
A
CLL
20
Q
Pseudo-Pelger-Hüet cells
Pawn ball megakaryocytes
Ringed sideroblasts
A
Myelodysplastic syndrome
21
Q
Tear drop cells (dacryocytes)
Leukoerythroblastosis
Osteosclerosis
Splenomegaly
A
Primary myelofibrosis
22
Q
Birbeck granules (tennis racket-like)
A
Langerhans cell hystiocytosis
23
Q
Gandy-Gamma nodules
A
Congestive splenomegaly
24
Q
Howell-Jolly bodies (post-splenectomy)
Spherocytes
A
Hereditary spherocytosis
25
Heinz bodies
| Bite cells
G6PD
26
Sickled cells
Codocytes (target cells)
Reticulocytosis
Howell-Jolly bodies
Sickle cell anemia
27
Basophilic stippling
Anisocytosis, poikilocytosis
Target cells
Micorcytic, hypochromic anemia
Thalassemia
28
Echinocytes / Burr cells
| Schistocytes
Microangiopathic hemolytic anemia
29
Walthard cell rests
Brenner tumor
30
Chocolate cyst
Endometriosis
31
Schiller-Duval bodies
Yolk sac tumor
32
Call-Exner bodies
Granulosa Cell Tumor
33
Flexner-Wintersteiner rosettes
Retinoblastoma
34
Drusen
| Choroidal neovascularization
Age-related macular degeneration
35
Hunner ulcers
Interstitial cystitis
36
Michaelis-Gutmann bodies
Malacoplakia
37
Erythroplasia of Qeyrat
Bowen disease
38
Schiller-Duval bodies
Yolk sac tumor
39
Helter-skelter collection of differentiated cells
Teratoma
40
Crystalloids of Reinke
Leydig cell tumor
41
Crystalloids of Charcot-Bottcher
Sertoli cell tumor
42
Hürthle cells
Hashimoto thyroiditis
43
Orphan Annie Nuclei
| Psammoma body
Papillary thyroid carcinoma
44
Water-clear cell hyperplasia
Parathyroid hyperplasia
45
Kimmelstiel-Wilson nodules
Nodular glomerulosclerosis (DM)
46
Renal papillary necrosis
Pyelonephritis
47
Nesidioblastosis
Giant islet cells
Amyloid deposits
Insulinoma
48
Necrolytic migratory erythema
a-cell tumors (glucagonomas)
49
Crooke hyaline change
Cushing syndrome
50
Spirinolactone bodies
Conn syndrome/ aldosterone-producing adenomas
51
Erlenmeyer flask deformity
Osteopetrosis
52
Mosaic pattern (jigsaw puzzle) of lamellar bone
Paget Disease of the bone
53
Nidus formation
Osteoid osteoma
54
Homer-Wright rosettes
| Onion-skin appearance of bone
Ewing Sarcoma
55
Ragged red fibers
| Parking lot inclusion
Mitochondrial myopathy
56
Heliotrope rash
| Gottron lesions
Dermatomyositis
57
Duret hemorrhages
| Kernohan's notch
Transtentorial herniation
58
Döhle bodies (toxic granules)
Sepsis
| Other high inflamm states (assoc w/ leukocytosis)
59
Paracortical hyperplasia
Chronic lymphadenitis
| assoc w/ EBV infx and phenytoin
60
Centroblasts
Centrocytes
Tingible-body macrophages
Follicular hyperplasia
61
Sinus histiocytosis (inc in # of size cells lining lymphatic sinusoids)
Breast CA
62
Popcorn cells
| Reed-Sternberg cells
Hodgkin's Lymphoma
63
Sézary-Lutzner cells
| Pautrier microabscesses
Mycosis fungoides
64
Hypoplasia of the arcuate nucleus
Hepatic extramedullary hematopoiesis
Periadrenal brown fat
SIDS
65
Port-wine stains
Hemangioma
66
Homer-Wright pseudorosettes
Neuropil
Blueberry muffin baby
Neuroblastoma
67
Blueberry muffin
Neuroblastoma
Congenital Rubella Syndrome
CMV infx
68
Homer-Wright Rosette
Neuroblastoma
Medulloblastima
Primitive Neuroectodermal Tumors (PNET)
69
Flexner-Wintersteiner Rosette
Retinoblastoma
70
True ependymal rosette
Ependymoma
71
Perivascular pseudorosette
```
Ependymoma
Medulloblastoma
PNET
Central neurocytom
Glioblastoma
```
72
Lead lines
Microcytic, hypochromic anemia
Saturnine gout
Lead poisoning
73
Milk and roses complexion
| Mee's lines
Arsenic poisoning
74
Ophthalmoplegia
Ataxia
Confabulation
Chronic alcoholism
| Wernicke-Korsakoff syndrome
75
Marjolin ulcers (overturned burn edges)
Squamous cell carcinoma of the skin
76
Trench foot
Hypothermia
77
Flag sign
| Flaky paint appearance
Kwashiorkor
78
Russel's sign
| calluses on the back of the hands
Bulimia Nervosa
79
Nyctalopia
Xerophthalmia
Keratomalacia
Vitamin A deficiency
80
Pseudotumor cerebri
Hepatitis
Bone pains
Vitamin A toxicity
81
```
Craniotabes
Genu varum
Rachitic rosary
Pigeon chest deformity
Tetany
```
Vitamin D deficiency
82
HyperCa
| Renal calculi
Vitamin D toxicity
83
Acrodermatitis enterohepatica
Diarrhea
Growth retardation
Zinc deficiency
84
Keshan disease
Selenium deficiency
85
Warthin-Finkeldey cells
| Koplik spots
Measles
86
Cowdry type A bodies
Herpes simplex infx
87
Ramsay Hunt syndrome
Varicella
88
Owl's eye inclusions (intranuclear basophilic inclusions)
| Heterophil (-) mononucleosis
CMV infx
89
Downey cells
| Heterophil (+) mononucleosis
EBV infx
90
Pastia's lines
| Strawberry tongue
Scarlet fever
91
Tumbling motility
Listeria monocytogenes
92
Swarming motility
Proteus mirabilis
93
Shooting star motility
Falling leaf motility
94
Boxcar-shaped gram (+) extracellular bacteria in chains
Bacillus anthracis
95
Slender beaded gram (+) arrranged in branching filaments
(+) Fite-Faraco
(-) granulomas
Nocardia asteroides
96
Haze of bacteria entangles with cilia on bronchial epith
Bordetella pertussis
97
Fleur-de-lis pattern
| Perivascular blue haze
Pseudomonas aeruginosa
98
Superficial zone of neutrophilic debris w/ underlying granulation tissue (painful genitla ulcer)
Chancroid (Hemophilus ducreyi)
99
Donovan bodies on Warthin-starry stain
| Pseudoepitheliomatous hyperplasia
Klebsiella granulomatis
100
Ranke's complex
Simon's focus
Ghon's focus
Langhan's type of giant cells
Mycobacterium tuberculosis
101
```
Lepra cells (red snappers)
Globi (multibacillary masses of acid-fast bacilli)
```
Lepromatous leprosy
102
Gummas
| Endarteritis
Tertiary syphilis
103
Erythrophagocytosis
Borrelia recurrentis
| Entamoeba histolytica
104
```
Erythema chronicum migrans
Lyme arthritis (onion skin-like lesions)
```
Borrelia burgdorferi
105
Stellate abscesses
Lymphagranuloma venereum (Chlamydia trachomatis)
106
Amount of tissue necrosis disproportionate to neutrophils and bacteria
Clostridium perfringens cellulitis
107
typhus nodules
| focal microglial proliferations w/ mixed T lymphocytes
Typhus fever (Rickettsia)
108
Soap bubble lesions
| yeasts grow in meninges and expand Virchow-Robin spaces
Cryptococcus neoformans
109
Hyphae within cavitations
| Necrotizing pneumonia
Aspergillus fumigatus
110
Necrotizing pneumonia
Aspergillus
Yersinia
Staph
Pseudomonas
111
Durck granulomas (ring hemorrhages)
Malaria
112
Schuffner's dots
P. vivax and ovale
113
Ziemann's dots
P. malariae
114
Maurer's dots
P. falciparum
115
Maltese cross pattern
Babesia microti
116
```
Mott cells
Capillary loops (parasites concentrate in choroid plexus and glomeruli)
```
Trypanosomiasis (African Sleeping Sickness)
117
Romaña's sign (unilat periorbital edema)
| Megacolon
Chagas disease (T. cruzi)
118
Nurse cells
Trichinella spiralis
119
Pipe-stem fibrosis
Severe schistosomiasis
120
Meyers-Kouvenaar bodies
Tropical pulmonary eosinophilia (Filariasis)
121
Lizard skin
Onchocercoma
Sclerosing keratitis (river blindness)
Onchocerca volvulus
122
```
Linitis plastica (leather bottle appearance)
Desmoplastic rxn
```
Gastric adenoCA
123
Salt-and-pepper chromatin
Carcinoid tumor
| Small cell lung CA
124
Intraepith lymphocytosis
Crypt hyperplasia
Villous atrophy
Celiac disease
125
Crypt abscesses
| Cryptitis
Campylobacter jejuni
126
Enlargement of Peyer's patches
Oval ulcers
Neutrophilic infiltration of lamina propria
Typhoid fever (Salmonella typhi)
127
PAS (+), diastase resistant granules
Distended foamy macrophages
Gram (+) actinomycete, Tropheryma whippelii
Malabsorptive diarrhea d/t impaired lymphatic transport
Whipple's disease
128
Paneth cell metaplasia
Noncaseating granulomas
Crypt abscesses
Crohn's disease
129
Backwash ileitis
Mucosal atrophy
(-) Mural thickening
Ulcerative colitis
130
Thin diverticular walls (absent muscularis propria)
| Epiploic appendices
Sigmoid diverticulitis
131
Arborizing networks
| Hamartomatous polyps
Peutz-Jehgers syndrome
132
Smooth nodular protrusions of mucosa
| Serrated architecture
Hyperplastic polyps
133
Epith dysplasia
Velvety texture
Pedunculated/ Sessile
Neoplastic polyps
134
Dysplastic epithelium
Desmoplastic response
Mucin accumulation
Signet-ring cells
Colorectal adenoCA
135
Ground-glass hepatocytes
Chronic Hepa B infx
136
Lymphoid aggregates
Bile duct reactive changes
Steatosis
Chronic Hepa C infx
137
Mallory bodies
Laennec cirrhosis
Hobnail appearance
Alcoholic hepatitis
138
Weibel-Palade bodies
Endothelial cell
139
Wire-loop capillaries
Type 4 lupus nephropathy
| Diffuse proliferative
140
Purpuric skin lesions in the extensor surfaces of extremities
(+) IgA deposits
1/3 -nephrotic
HSP
141
Immune complex nephritis initiated by bacterial Ag
Bacterial endocarditis
142
Protein level in UA in nephrotic syndrome
>3.5 g / 24h
143
Papillary necrosis
Pyelonephritis
144
Kimmelsteil-Wilson nodules (nodular glomerulosclerosis)
Fibrin caps
Capsular drops
DM nephropathy
145
Tamm-Horsfall protein
| (+) hyaline and granular cast
ATN
146
Bence Jones protein
| Tamm Horsfall proteins
Multiple myeloma
