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more antibiotics Flashcards

1
Q

first effective chemotherapeutic agent for bacterial infections

A

sulfonamides

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1
Q

sulf class

A

sulfonamide

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2
Q

sulfonamide MOA

A

competitive PABA inhibitor –> folic acid synthesis inhibitor

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3
Q

sulfonamide bacter-

A

bacteriostatic

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4
Q

sulfonamide targets

A

staph aureus, e. coli, pneumocystis jiroveci

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5
Q

sulfonamide indications

A

skin + soft tissue infections, UTIs, pneumocystis pneumonia

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6
Q

sulfonamide warnings

A

DDI: warfarin
cross-allergenicity: glipzide, furosemide, hydrochlorothiazide
pregnancy category C

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7
Q

cycline class

A

tetracycline

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8
Q

tetracycline MOA

A

30S bacterial ribosome inhibitor

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9
Q

tetracycline bacter-

A

bacteriostatic

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10
Q

tetracycline indications

A

lyme disease**

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11
Q

tetracycline ADEs

A

tooth enamel hypoplasia, permanent tooth discoloration

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12
Q

tetracycline BBW

A

tigecycline –> increased all-cause mortality

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13
Q

tetracycline warnings

A

DDI: multivalent cations
don’t avoid doxycycline for RMSF regardless of age**
pregnancy category d

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14
Q

floxacin class

A

fluoroquinolones

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15
Q

fluoroquinolone MOA

A

topoisomerase I + IV inhibitor

16
Q

fluoroquinolone bacter-

A

bactericidal

17
Q

fluoroquinolone indications

A

community-acquired pneumonia (EXCEPT CIPROFLOXACIN), UTIs (EXCEPT MOXIFLOXACIN), serious systemic gram - bacterial infections

18
Q

fluoroquinolone ADEs

A

QTc prolongation

19
Q

fluoroquinolones BBW

A

tendinopathy

20
Q

fluoroquinolone warnings

A

DDI: multivalent cations + QTc prolongation drugs
pregnancy category C

foundations (14 decks)

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