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foundations > diabetes > Flashcards

diabetes Flashcards

1
Q

formin MOA

A

decreases hepatic glucose production + intestinal absorption of glucose, increase insulin sensitivity in muscles

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2
Q

formin BBW

A

lactic acidosis

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3
Q

formin ADEs

A

vitamin B deficiency, lactic acidosis

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4
Q

diabetes drugs with high A1C reduction

A

biguanides, sulfonylureas, GLP-1 agonists, thazolidinediones

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5
Q

diabetes drugs w/ hypoglycemia risk

A

sulfonylureas, meglitinides

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6
Q

diabetes drugs w/ weight gain

A

sulfonylureas, thiazolidinediones

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7
Q

most weight gain diabetes drug

A

tirzepatide (manjaro)

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8
Q

most well-tolerated diabetes drug

A

DPP-4 inhibitors

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9
Q

formin chemical class

A

biguanide

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10
Q

amide, ride, zide, gli, glu chemical class

A

sulfonylureas

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11
Q

sulfonylurea MOA

A

increase secretion of insulin in pancreatic B cells

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12
Q

diabetes highest hypoglycemia risk

A

glyburide

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13
Q

sulfonylurea disadvantage

A

B cell burnout

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14
Q

gliflozan chemical class

A

SGLT2 inhibitor

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15
Q

gliflozan MOA

A

decreased reabsorption of glucose, increase glucose excretion

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16
Q

gliflozan indications

A

HF

17
Q

gliflozan disadvantages

A

UTIs

18
Q

gliptin chemical class

A

DPP-4 inhibitor

19
Q

gliptin MOA

A

increase incretins + insulin, decrease glucagon

20
Q

gliptin ADEs

A

respiratory tract infection + nasopharyngitis, joint pain

21
Q

gliflozan ADEs

A

genitourinary infections, necrotizing fascilis + ketoacidosis, amputation + bone fractures

22
Q

gliflozan contraindications

A

renal disease

23
Q

gliptin contraindications

A

pancreatitis, HF

24
Q

tide chemical class

A

GLP-1 agonist

25
Q

tide MOA

A

increase insulin + B cells, decrease glucagon + gastric emptying

26
Q

tide indications

A

weight management (liraglutide, semiglutide)

27
Q

tide contraindications

A

thyroid, endocrine neoplasm, pancreatitis

28
Q

tide advantages

A

ASCVD protection

29
Q

glitazone chemical class

A

thazolidinediones

30
Q

glitazone MOA

A

activates PPAR, decrease insulin resistance

31
Q

glitazone contraindications

A

class III-IV HF

32
Q

glitazone ADEs

A

edema, increased risk of bladder cancer + fractures

33
Q

glinide chemical class

A

meglitinides

34
Q

glinide MOA

A

secrete insulin in pancreatic B cells

35
Q

glinide ADEs

A

respiratory infection

36
Q

acarbose, miglitol chemical class

A

a glucosidase inhibitors

37
Q

acarbose, miglitol MOA

A

inhibits hydrolyzation of carbs, delays glucose absorption, decrease postprangial glucose

38
Q

acarbose, miglitol contraindications

A

GI, ketoacidosis, cirrhosis

foundations (14 decks)

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