antiretrovirals Flashcards
1
Q
standard ART
A
2 NRTIs + 1 active agent from another class (triple therapy)
2
Q
fovir, vudine, cavir class
A
NRTIs
3
Q
NRTIs for HBV
A
tenofovir, emtricitabine, lamivudine
4
Q
NRTI eliminations
A
renally (except abacavir)
5
Q
navir class
A
NNRTIs
6
Q
NNRTIs ADEs
A
hepatotoxicity, rash
7
Q
DDI more common in NRTI vs NNRTI
A
NNRTI
8
Q
NNRTIs DDI
A
CYP3A4, acid suppressants (rilpivirine)
9
Q
navir class
A
protease inhibitor
10
Q
navir ADEs
A
increased GI + metabolic toxicity
11
Q
navir 3A4 inhibition causes
A
increased bioavailability, decreased risk of resistance
12
Q
tegravir class
A
INSTI
13
Q
INSTI ADEs
A
well-tolerated
14
Q
elvitegravir requirement
A
booster (COBI)
15
Q
entry inhibitors
A
maraviroc, ibalizumab, fostemsavir
