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antifungals Flashcards

1
Q

antifungals for invasive

A

tericin, tin –> polyene
conazole –> triazoles
fungin –> echinocandin
cytosine –> fluoropyrimidine

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2
Q

antifungals for superficial

A

ketoconazole + azole –> imidazoles
nystatin –> polyene
fungerp –> triterpenoid

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3
Q

tericin, tin fungi-

A

fungicidal

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4
Q

tericin, tin MOA

A

binds ergosterol –> cell lysis via pores

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5
Q

tericin, tin indications

A

cryptococcal meningitis, candida endocarditis, mucormysis, aspergillus

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6
Q

tericin, tin ADEs

A

nephrotoxicity**, infusion rxn, electrolyte abnormalities

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7
Q

conazole fungi-

A

fungistatic

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8
Q

conazole MOA

A

ergosterol synthesis inhibitor

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9
Q

conazole indications

A

fluconazole –> candidiasis, prophylaxis
voriconazole –> aspergillosis
posaconazole –> prophylaxis
isavuconazole –> mucormycosis

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10
Q

conazole ADEs

A

–QTc prolongation** (except isavu)
–visual changes, photosensitivity (vori)

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11
Q

conazole DDI

A

CYP450

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12
Q

conazole narrowest + broadest spectrum

A

narrowest –> fluconazole
broadest –> posaconazole + isavuconazole

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13
Q

fungin fungi-

A

fungicidal –> candida
fungistatic –> molds

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14
Q

fungin MOA

A

glucan synthesis inhibitor

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15
Q

fungin indications

A

candidiasis, aspergillus

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16
Q

fungin ADEs

A

well-tolerated

17
Q

cytosine MOA

A

inhibits protein, DNA, RNA, synthesis

18
Q

cytosine indications

A

candida, cryptococcus

19
Q

cytosine ADEs

A

bone marrow suppression**, hepatotoxicity, GI (from metabolism to fluorouracil)

20
Q

cytosine warnings

A

avoid monotherapy

21
Q

ketoconazole + azole fungi-

A

fungistatic

22
Q

ketoconazole + azole MOA

A

ergosterol synthesis inhibitor

23
Q

ketoconazole + azole indications

A

dermatophytes, mucocutaneous candida**

24
Q

nystatin MOA

A

binds ergosterol –> cell lysis via pores

25
Q

nystatin indications

26
Q

fungerp MOA

A

protein + glucan synthesis inhibitor

27
Q

fungerp indications

A

resistant candida, vulvovaginal candidiasis

28
Q

fungerp ADEs

A

–well tolerated

29
Q

fungerp contraindications

30
Q

conazole strong inhibitor

A

itraconazole, voriconazole, poriconazole

31
Q

conazole best for aspergillus

A

voriconazole

32
Q

what can treat aspergillus

A

tericins, voriconazole, echinocandin, azoles except fluconazole, fungerp

foundations (14 decks)

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