even more antibiotics

Question 1

macrolide names

Answer 1

erythromycin, azithromycin, clarithromycin, fidaxomicin

Question 2

macrolide MOAs

Answer 2

erythromycin, azithromycin, clarithromycin –> 50S ribosomal subunit inhibitor
fidaxomicin –> RNA polymerase inhibitor

Question 3

macrolide bacter-

Answer 3

erythromycin, azithromycin, clarithromycin –> bacteriostatic
fidaxomicin –> bactericidal

Question 4

macrolide indications

Answer 4

erythromycin, azithromycin, clarithromycin
–community-acquired pneumonia
–pertussis
–pharyngitis
–chlamydia
–gonorrhea
–h. pylori infections

fidaxomicin
–c. diff infections**

Question 5

macrolide ADEs

Answer 5

–nausea: erythromycin&raquo_space; azithromycin, clarithrymycin
–dysgeusia (clarithromycin)
–QTc prolongation**
–hepatotoxicity

Question 6

macrolide warnings

Answer 6

–increased risk of all-cause + cardiovascular mortality (azithromycin + clarithromycin)
–QTc prolongation (azithromycin)

Question 7

lincosamide names

Answer 7

lincomycin, clindamycin

Question 8

lincosamide MOA

Answer 8

50S ribosomal subunit inhibitor, inhibits toxin production in necrotizing infections

Question 9

lincosamide bacter-

Answer 9

bacteriostatic

Question 10

lincosamide indications

Answer 10

–necrotizing fasciitis
–aspiration pneumonia** (clindamycin)
–bacterial vaginosis
–pneumocystis pneumonia
–toxoplasmosis

Question 11

lincosamide MRSA

Answer 11

clindamycin

Question 12

lincosamide warnings

Answer 12

clindamycin high risk for c. diff**

Question 13

aminoglycoside names

Answer 13

streptomycin, neomycin, paromomycin, gentamicin, tobramycin, amikacin, plazomicin

Question 14

aminoglycoside MOA

Answer 14

30S ribosomal subunit inhibitor
–concentration dependent**
–post-antibiotic effect**

Question 15

aminoglycoside bacter-

Answer 15

bactericidal

Question 16

aminoglycoside indications

Answer 16

pseudonomas, gram -

Question 17

aminoglycoside ADEs

Answer 17

–nephrotoxicity (reversible)**
–ototoxicity (irreversible)**
–neuromuscular blockade

Question 18

glycopeptide names

Answer 18

vancomycin

Question 19

glycopeptide MOA

Answer 19

inhibits cell wall synthesis by binding peptidoglycan precursors
–time + concentration dependent**

Question 20

glycopeptide bacter-

Answer 20

bactericidal

Question 21

glycopeptide indications

Answer 21

–gram positive infections (IV)**
–c. diff infections (PO)**

Question 22

glycopeptide 1st line for

Answer 22

MRSA

Question 23

floxacin spectrum of activity

Answer 23

broad spectrum