mood disorders Flashcards

1
Q

what is thee clinical picture of depression ?

A

5 or ore of thee following for a period of 2 weeks
category A and category B symptoms

A - depressed mood
loss of interest
low energy

B -reduced concentration
reduced self esteem
ideas of guilt
change in appetite
sleep disturbances
ideas off self harm

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2
Q

what are the criteria for the diagnosis of mild, moderate or severe depression ?

A

mild 2 A + 2 B

moderate 2 A + 4 B

severe all of A and 5 of B

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3
Q

what is cotrads syndrome ?

A

patient has a delusional belief that they are dead and is ususally associated with severe depression

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4
Q

chronic depression that is not fulfilling the criteria for major depression ?

A

dysthymia

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5
Q

what is adjustment disorder with depressed mood ?

A

mild to moderate symptoms off depression
occurred and disappeared within 6 months of significant stressor

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6
Q

what is the first line treatment for mild to moderate depression that has failed intial interventions ?

A

SSRI
or
CBT
or
IPT

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7
Q

what is the first line management for moderate to severe depression ?

A

SSRRI and CBT or IPT

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8
Q

what type of patients are likely to benefit from ECT ?

A

severe depression with life threatening

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9
Q

what is the difference between bipolar 1 and 2 ?

A

1 - mania has occurred on at least one occasion
2 - hypomania has occurred on at least one occasion

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10
Q

what is hypomania ?

A

elevated or irritable state sustained for at least 4 days

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11
Q

what is mania ?

A

elevated or irritable sustained for 1 week

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12
Q

what are the variants of bipolar disorder ?

A

rapid cycling - 4 or more episodes per year
cyclothymia - milder form of bipolar , doesn’t meet the criteria

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13
Q

what is the kindling effect ?

A

initial episodes of a mood disorder are more likely to be influenced by psychosocial stressors compared to later episodes

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14
Q

what is thee treatment for an acute episode of mania or hypomania ?

A

lithium
valproate
antipsychotics

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15
Q

what is thee treatment of bipolar depression in the acute setting ?

A

valproate
quetiapine
lamotrigine
lithium

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16
Q

what is thee treatment for maintenance in bipolar patients ?

A

lithium
valproate
olanzapine

17
Q

what are thee side effects of lithium ?

A

abdominal pain
nausea
metallic taste in mouth
fine tremor
thirst
polyuria
teratogenic
hypothyroidism
nephrogenic diabetes insipidus

18
Q

what are the clinical features of lithium toxicity ?

A

Coarse tremor
Central nervous system disturbance, which may include seizures, impaired coordination, and dysarthria
Cardiac arrhythmias
Visual disturbance

19
Q

what is the side effect off sodium valproate ?

A

teratogenic
can cause deafness
blood and bone marrow problems
abnormal eye movement

20
Q

what are thee contraindications of sodium valproate ?

A

women of child bearing age and pregnant women

21
Q

what are the side effects of lamotrigine ?

A

skin rash including stevens- Johnson or TEN

22
Q

what are examples of atypical antipsychotics ?

A

second generation antipsychotics
like respiridone
olanzapine

23
Q

what are the side effects of second generation anti psychotics ?

A

postural hypotension
abnormal gait
weight gain
metabolic problems

24
Q

what is the association between creativity and bipolar disease ?

A

inverted U hypothesis