Mood 2 Nerodevelopment Flashcards

1
Q

fetal stress can

A

permanently change fetal brain development

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2
Q

Fetal Alcohol Syndrome

A

interferes with embryonic/fetal development

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3
Q

FASD

A

fetal alcohol spectrum disorders

physical, behavioral, cognitive, neural impairments

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4
Q

FAS Causes

A

alcohol abuse during pregnancy

birth-induced morphologic injury & developmental disabilities

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5
Q

FAS s/s

A

deficiency in weight/height
abnormalities in development of nervous system
thin upper lip
smooth philtrum (smooth between nose and lip)
small palpebral fissures

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6
Q

HIV-positive infants

A

delayed neurodevlopment

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7
Q

Maternal Depression on child development

A

ADD/hyperactivity disorder
oppositional defiant disorder
lower levels of social engagement/empathy

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8
Q

large genetic components in which disorders

A

autism spectrum disorder

intellectual disability

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9
Q

advanced paternal age plays role in

A

autism
bipolar disorder
schizophrenia

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10
Q

advanced maternal age plays role in

A
down syndrome (trisomy 21)
autism and other
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11
Q

Down syndrome

A

most common chromosomal condition
intellectual disability and other serious morbidity
can be subtle w/ not all features

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12
Q

Down syndrome pathogenesis

A

chromosome 21 trisomy

total intracranial volume smaller, especially cerebellum/brainstem/frontal lobes

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13
Q

down syndrome s/s

A
facial characteristics
short stature
dysmorphism
growth delays
hearing problems
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14
Q

down syndrome tx

A

no known cure
pt/ot
speech therapy
family interventions (sign language/visual cues)

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15
Q

autism spectrum disorder s/s

A

series of deficits in social interaction & communication
restricted, repetitive stereotyped behavior patterns
anxiety disorders

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16
Q

autism spectrum disorder dx

A

based on child’s behavior & development

MMR does not cause autism

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17
Q

autism spectrum disorder tx/interventions

A

discrete trial training
comprehensive behavioral treatment
joint attention intervention
self-management

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18
Q

Psychosis

A

symptom rather than disorder

abnormal thought processes interfering significantly with perceptions of reality

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19
Q

psychosis associated with

A
underlying illness or substance use,
schizophrenia
trauma
severe peripartum depression 
bipolar disorder
stroke
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20
Q

mean duration of untreated psychosis

A

364-721 days

longer = pooer outcome

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21
Q

psychosis assessment

A

toxicology screening
screening for suicidal ideation/self-injurious behavior
referral for further evaluation by mh provider
special considerations in pregnant/postpartum women

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22
Q

Schizophrenia

A

devastating long-term mental disorder
breakdown between thought, emotion, behavior
faulty perception
inappropriate actions & feelings,
withdrawal from reality/personal relationshps into fantasy/delusion
hallucinations
mental fragmentation

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23
Q

schizophrenia manifests men/women

A

15-24

25-34

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24
Q

schizophrenia etiology/pathogenesis

A
cause not known
may be genetic
1% of world's population 
similar rates across ethnicities
very variable 
childhood trauma usually
increased levels of cytokines
neurotransmitter abnormalities/impaired immune fx
neuronal malformation
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25
Q

schizophrenia formal thought disorder

A
altered thought processes
pressured/distracted speech
poverty of speech
loose associations
word salad
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26
Q

schizophrenia s/s

A
social withdrawal
abnormal movements
memory & attention 
loss of executive function 
avolition (reduced ability to engage in goal-directed behavior)
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27
Q

schizophrenia positive symptoms

A
additions to normal experiences
delusions
hallucinations
abnormal movements
formal thought disorder
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28
Q

schizophrenia negative sympotoms

A
diminished affects/behaviors
flat/blunted affect
thought blocking
avolition
poverty of speech
social withdrawal
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29
Q

schizophrenia cognitive symptoms

A

memory deficits
attention deficits
language difficulties
loss of executive function

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30
Q

schizophrenia dx

A

predictors of fx in early dx parallel factors that predict fx chronically
clinical signs persist for at least 6 months
lack of clinical insight one of most important features

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31
Q

schizophrenia tx

A

pharm (limited effectiveness) [no single drug of choice, depends on pt]
cognitive enhancement approaches
tailored interventions
traditional clinic-based cognitive &psychosocial rehab
family psychoeducation

32
Q

schizophrenia tx goal

A

to reduce psychotic symptoms

drugs do not cure mental illness but must continue drug regimen to remain in remission

33
Q

conventional antipsychotics

A

phenothiazines, chlorpromazine (first generation)

nonphenothiazines

34
Q

atypical antipsychotics

A
second generation (70s/80s)
less side effects
35
Q

atypical antipsychotics

A

new -10 years

dopamine-serotonin system stabilizers (aripiprazole)

36
Q
chloropromazine
thioridazine
fluphenazine
perphenazine
procchlorperaine
trifluperazine
A
PHENOTHIAZINES
first generation antipsychotics
tx positive symptoms
takes 7-8 weeks
injections can tx extreme agitation 
preg c
37
Q

Phenothiazines se, bbw, contra, intx

A

chloropromazine
blocked alpha-adenergic receptors
weak blocking of cholinergic receptors
dizziness, drowsiness, orthostatic hypotension
anticholinergic effects, secondary parkinsonism, sedation, sexual dysfunction, tardive dyskineasia akathisia, acute dystonia (severe spasms/tiwtching movements), risk for suicide, high fever/serum ceatine kinase
bbw: in elderly pts w/ dementia pyschosis = risk for death
contra: alcohol withdrawal, comatose state, subcortical brain damage, bbd, reye’s syndrome
intx: TCAS = ^ BP, antiseizure meds: lower seizure threshold, kava/st. john’s wort increase severity of dystonia

38
Q

tardive dyskinesisas

A

lip smacking
wormlike movements of tongue
uncontrolled chewing/grimacing

39
Q

haloperidol

A

phenylbutyliperadine
first gen antipsychotic
blocks dopamine type 2 receptor
tx sever acute/chronic psychotic disorders, tourette’s syndrome

40
Q

haloperidol se, bbw, contra, interx

A

first gen antipsychotic
sedation, hypotension, ^ extrapyramidal symptoms
bbw: elderly w/ dementia r/t psychosis = ^ risk for death
contra: meds for parkinson’s, seizure disorders, alcoholism, severe mental depression
interx: antacids, levodopa, lithium, phenobarbital, phenytoin, rifampin, beta-blockers, kava

41
Q

extrapyramidal symptoms

A

acute dystonias
akathisia
secondary/pseudo-parkinsonism
tardive dyskinesias

42
Q

risperidone
quetiapine
olanzapine
ziprasidone

A

benzisoxazole
second generation atypical antipsychotic
blocks dopamine type 2 receptors, serotonin, aa receptors
tx positive and negative symptoms and prevention of schizo relapse/expression of mania
C
risperidone tx autism

43
Q

benzisoxazole se, bbw, contra, intx, overdose

A

risperidone
< than first gens
obesity, hyperglycemia, some extrapyramidal symptoms, hyperactivity, fatigue, n, dizziness, visual disturbances, fever, orthostatic hypotension
bbw: elderly w/ dementia = risk for death
contra: heart failure, pneumonia, dysrhythmias, hypotension, seizures, suicidal ideations, kidney/liver disease
intx: kava, valerian, chamomile SSRIs, antifungals (liver), clozapine (kidneys)
overdose: activated charcoal

44
Q

aripiprazole

A

Quinolinone
second gen
tx: autism, bipolar, tourette’s, major depressive disorder, schizophrenia

45
Q

aripiprazole se, bbw, contra, interx

A

quinolinone
weight gain, constipation, n/v, dizziness, extrapyramdial signs, sedation
SEVERE: pancreatitis, agranuloctosis, suicidal behavior, angioedma, neuroleptic malignant syndrome
bbw: elderly w/ dementia = death
contra: ketoconazole, ziprasidone, saquinavir, amisulpride, metoclopramide, amiodarone, prolonged QT intervals
interx: CNS depressants
no preg

46
Q

Dementia causes

A

illnesses, head trauma
alzheimer (more than 50%)
vascular dementia (following series of small strokes)

47
Q

dementia s/s

A

slow, progressive decline of cognitive fx
alzheimer’s vs vascular dementia
eventually unable to care for self/communicate

48
Q

dementia tx

A
monitoring
reinforcing orientation x3
encouraging establishment of advance directives
drugs will only delay progression 
break things into steps that are simple
49
Q

alzheimer’s

A

causes 70% of all dementia
progressive loss of brain fx (memory loss, confusion, dementia, fx, behavior)
associated w/ cerebral atrophy

50
Q

alzheimer’s structural damange

A

hippocampus (learning/memory)

decreases number/fx of neurons

51
Q

alzheimer’s s/s

A
impaired memory/judgment
confusion/disorientation 
can't recognize fam/friends
agressive
depression
psychoses
anxiety
52
Q

alzheimer’s drug therapy

A

no cure
intensify acetylcholine
modest efficacy
ineffective in late stages

53
Q

donepezil
galantamine
rivastigmine
memantine

A
cholinesterase inhibitors
alzheimer's disease drugs
prevent breakdown of acetylcholine
slows progression of disease
used all through
54
Q

cholinesterase inhibitor se, overdose, contra, intx

A

donepezil/-mines (alzheimer’s drugs)
v/n, dizziness, headache, abnormal dreams, irritability, darkened urine, htn, syncope, increased creatine kinase level, musculoskeletal cramps, AV block, torsades
overdose: atopine (anticholinergic)
contra: gi bleed, jaundice, -floxacins, oxybutynin (seizures)
reduce effectiveness of anticholinergics

55
Q

tension headaches

A

pericranial mofascial pain

56
Q

tension headaches causes

A

excessive contraction, ischemia, inflammation of neck/scalp muscles
emotional stress, inadequate rest
poor posture

57
Q

tension headaches s/s ,, tx

A

constant, bilateral, dull, nonthrobbing bandlike pain

aspirin, acetominophen, nsaids

58
Q

migraine

A

chronic complex, neurovascular disorder

59
Q

migraine causes

A
genetics
triggers:
diet
hormones
environment
altitude
stress
sleep
noise
odors
60
Q

migraine s/s

A

throbbing, pulsing unilateral headache
n/v
sensitivity to light/sound
aura

61
Q

migraine dx

A

w/ or w/out aura

specific criteria

62
Q

migraine tx

A

prophylactic therapy
acute abortive therapy
complementary therapy
opiates can cause rebound headache

63
Q

migraine phases

A

prodrome 50% (increased/decreased perception, irritability/withdrawal, food cravings, yawning, speech difficulties, 24 h prior to overt migraine)
aura 20% (visual disturbances, numbness/tingling in hands, dysphagia, olfactory, auditory changes, 30-60 min before ha, lasts 5-60 min)
headache (4-72 h)
prodrome (fatigue, aching muscles, euphoria, lasts up to 24 h)

64
Q

cluster headache

A

unilateral severe pain associated w/ ipsilateral cranial autonomic symptoms

65
Q

cluster headache s/s

A

sudden onset

severe, piercing unilateral pain behind/around eye

66
Q

cluster headache tx

A

subQ or nasal tiptans, dihydroergotamine
100% o2
occipital nerve blocks

67
Q

headache danger signs

A
sudden new/severe
progressively worsening
onest after exertion, straining, coughing, sexual activity
n/v
onset after age 50
68
Q
sumatriptan
fovatiptan
naratriptan
rizatriptan
almotriptan
zolmitriptan
eletriptan
A

serotonin receptor agonist
migraine abortive agents
vasoconstriction in brain
tx migraine (acute) or cluster ha

69
Q

serotonin receptor agonist se, vvw, contra, interx

A

-triptans
painful injection site, abnormal sensation ,dizziness, numbness vertigo, cardiac arrest, dysrhythmia, htn crisis, splenic infarction, cerebral hemorrhage, serotonin syndrome
contra: moa inhibitors, ischemic bowel or cardiac disease, peripheral vascular disease, uncontrolled htn, severe hepatic impairment, wolff-parknson-white syndrome
interx: citalopram, escitalopram, fluoxetine, paroxetine, (ssris), hydromorphone, hydrocodone, amphetamines, sertaline

70
Q

ergotamine tartrate
dihydroergotamine
isometheptene mucate

A

ergotamine derivatives
migraine abortive agents
tx migraines, vascular ha

71
Q

ergotamine derivatives se, bbw, contra, interx

A

aortic value fibrosis, cyanosis, ekg abnormalities, precordial pain, retoperitoneal fibrosis, pulmonary fibrosis
bbw: sl tablets = severe peripheral ischemia given w/ CYP3A4 inhibitors/macrolide abx
contra: -virs, clarithromycin, -conazole, protease inhibitors)
interx: beta blockers, metronidazole
x

72
Q

botox

A

botulinum toxin type a
chronic migraine prophylaxis
blocks neuromuscular conduction
tx chronic migraine, bladder muscle dysfx, hyperhidrosis of axilla

73
Q

botox se, bbw, contra

A

injection site pain, ha, dry eyes, urinary retention, overactive bladder, cough, rhintis, dysrhythmias, dysphagia, autonomic dysreflexia, seizure

bbbw: may spread toxins w/ powder upon reconstitution
contra: UTI, urinary retention, increased pvr, pregnancy, lactations

74
Q

other migraine agents

A
betablockers
verapamil
divalproex
topiramate
gabapentin
fluoxetine
amitriptyline
75
Q

bell’s palsy

A

acute peripheral facial nerve palsy

risk 3x greater during pregnancy

76
Q

bell’s palsy s/s

A

sudden unilateral facial paralysis

eyebrow sagging/inability to close eye, drooping mouth, prodromal ear pain

77
Q

bell’s palsy dx/tx

A

rule out cva, lyme disease, gbs, tumor

glucocorticoid
antiviral therapy
eye patch/artificial tears