Monoclonal Antibodies

Question 1

Infliximab

Answer 1

Anti-TNF

Used in rheumatoid arthritis and Crohn’s disease

Question 2

Adalimumab

Answer 2

TNF-alpha blocker

Used in ankylosing spondylitis

Question 3

Denosumab

Answer 3

Rank ligand antagonist

Used in osteoporosis

Question 4

Rituximab

Answer 4

Anti-CD20

Used in non-Hodgkin’s lymphoma and rheumatoid arthritis

Question 5

Cetuximab

Answer 5

Epidermal growth factor receptor antagonist

Used in metastatic colorectal cancer and head and neck cancer

Question 6

Trastuzumab

Answer 6

HER2/neu receptor antagonist

Used in metastatic breast cancer

Question 7

Alemtuzumab

Answer 7

Anti-CD52

Used in chronic lymphocytic leukaemia, MS

Question 8

Abciximab

Answer 8

Glycoprotein IIb/IIIa receptor antagonist

Used to prevent ischaemic events in patients undergoing PCI

Question 9

Tocilizumab

Answer 9

IL6 blocker

Question 10

OKT3

Answer 10

Anti-CD3

Used to prevent organ rejection

Question 11

Abatecept

Answer 11

Inhibits T cell activation

Question 12

Imatinib

Answer 12

Tyrosine kinase inhibitor

Used in CML and ALL as TK is increased due to Philadelphia chromosome