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Medicine Extras > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Mnemonic for protein synthesis inhibiting antibiotics

A

A good antibiotic merchant buys AT30 and CELLS at 50.

  • 30S Subunit = A + T = Aminoglycosides + Tetracyclines
  • 50S Subunit = CELLS = Chloramphenicol + Erythromyccin (Macrolides) + Linezolid + cLindamycin (Lincosamide) + Streptogrammins
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2
Q

Macrolide examples

A

Clarythromycin, Erythromycin

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3
Q

Macrolide action

A

50S Subunit of Ribosome > Block Protein Synthesis

Buys AT30 and C[E]LLS at 50
»»[E] as in [E]rythromycin

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4
Q

Aminoglycoside examples

A

Gentamicin

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5
Q

Aminoglycoside action

A

30S Subunit of Ribosome > Block Protein Synth

Buys [A]T30 and CELLS at 50

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6
Q

Tetracycline examples

A

Doxycycline, Tetracycline

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7
Q

Tetracycline action

A

30S Subunit of Ribosome > Blocks Protein Synth

Buys A[T]30 and CELLS at 50

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8
Q

Lincosamide examples

A

cLINdamycin

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9
Q

Lincosamide action

A

50S Subunit of Ribosome > Blocks Protein Synth

Buys AT30 and CEL[L]S at 50

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10
Q

B-Lactam examples

A

Amoxicillin, flucloxacillin, methylpenicillin

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11
Q

B-Lactam action

A

Inhibits the cross-linking of peptidoglycan cell walls.

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12
Q

Glycopeptide examples

A

Vancomycin

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13
Q

Glycopeptide action

A

Inhibits the polymerisation of peptidoglycan cell walls.

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14
Q

Dihydrofolate-Reductase examples

A

Trimethoprim

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15
Q

Dihydrofolate-Reductase action

A

Blocks folate synthesis and thus prevents DNA synthesis.

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16
Q

Quinolone examples

A

Ciprofloxacin, moxifloxacin.

17
Q

Quinolone action

A

Prevent DNA synthesis via inhibition of topoisomerase and DNA gyrase.

18
Q

Cephalosporin examples

A

Cephotaxime, Ceftriaxone.

19
Q

Cephalosporin action

A

B-Lactam which prevent the cross-linking of peptidoglycan in cell walls.

20
Q

Carbapenem examples

A

Imipenem

21
Q

Carbapenem action

A

B-lactam which prevent the cross-linking of peptidoglycan in cell walls.

22
Q

Rifampcin action and main side effect

A

Think R R R: Rifampcin, RNA, Red

Inhibits RNA synthesis.

Side effect: Red/Orange urine, sweat, and tears.

23
Q

What class of abx is Cephotaxime?

A

Cephalosporin

24
Q

What class of abx is Vancomycin?

A

Glycopeptide

25
Q

What class of abx is Doxycycline?

A

Tetracycline

26
Q

What class of abx is Gentamicin?

A

Aminoglycoside

27
Q

What class of abx is Erythromycin?

A

Macrolide

28
Q

What class of abx is Trimethoprim?

A

Dihydrofolate reductase inhibitor

29
Q

What class of abx is Flucloxacillin?

A

B-Lactam

30
Q

What class of abx is Ciprofloxacin?

A

Quinolone

31
Q

What is the action of Doxycycline?

A

Blocks 30S subunit of bacterial ribosomes

(Buys A[T]30 and CELLS at 50).

32
Q

What is the action of Clarythromycin?

A

Blocks 50S subunit of bacterial ribosomes

Buys AT30 and C[E]LLS at 50
»>Referring to [E]rythromycin.

33
Q

What is the action of Trimethoprim?

A

Inhibits dihydrofolate reductase which prevents folate metabolism which prevents DNA synthesis.

34
Q

What is the action of Gentamicin?

A

Blocks 30S subunit of bacterial ribosomes

Buys [A]T30 and CELLS at 50
»>Reffering to [A]minoglycosides

35
Q

What is a side-effect of Aminoglycosides?

A

Long QT > Torsades des pointes

36
Q

What is the action of Vancomycin?

A

Prevents peptidoglycan polymerisation and thus prevents cell-wall synthesis.

37
Q

What is the action of Ciprofloxacin?

A

Prevents DNA synthesis by inhibition of DNA gyrase and topoisomerase.

38
Q

What is the action of Metronidazole?

A

MetroniDAzole

Damages DNA once it has been reduced (Predominantly by anaerobic organisms).

39
Q

What is the action of Chlopramphenicol?

A

Blocks 50S subunit of bacterial ribosomes

Buys AT30 and [C]ELLS at 50

Medicine Extras (24 decks)

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