Antibiotics Flashcards
Mnemonic for protein synthesis inhibiting antibiotics
A good antibiotic merchant buys AT30 and CELLS at 50.
- 30S Subunit = A + T = Aminoglycosides + Tetracyclines
- 50S Subunit = CELLS = Chloramphenicol + Erythromyccin (Macrolides) + Linezolid + cLindamycin (Lincosamide) + Streptogrammins
Macrolide examples
Clarythromycin, Erythromycin
Macrolide action
50S Subunit of Ribosome > Block Protein Synthesis
Buys AT30 and C[E]LLS at 50
»»[E] as in [E]rythromycin
Aminoglycoside examples
Gentamicin
Aminoglycoside action
30S Subunit of Ribosome > Block Protein Synth
Buys [A]T30 and CELLS at 50
Tetracycline examples
Doxycycline, Tetracycline
Tetracycline action
30S Subunit of Ribosome > Blocks Protein Synth
Buys A[T]30 and CELLS at 50
Lincosamide examples
cLINdamycin
Lincosamide action
50S Subunit of Ribosome > Blocks Protein Synth
Buys AT30 and CEL[L]S at 50
B-Lactam examples
Amoxicillin, flucloxacillin, methylpenicillin
B-Lactam action
Inhibits the cross-linking of peptidoglycan cell walls.
Glycopeptide examples
Vancomycin
Glycopeptide action
Inhibits the polymerisation of peptidoglycan cell walls.
Dihydrofolate-Reductase examples
Trimethoprim
Dihydrofolate-Reductase action
Blocks folate synthesis and thus prevents DNA synthesis.
Quinolone examples
Ciprofloxacin, moxifloxacin.
Quinolone action
Prevent DNA synthesis via inhibition of topoisomerase and DNA gyrase.
Cephalosporin examples
Cephotaxime, Ceftriaxone.
Cephalosporin action
B-Lactam which prevent the cross-linking of peptidoglycan in cell walls.
Carbapenem examples
Imipenem
Carbapenem action
B-lactam which prevent the cross-linking of peptidoglycan in cell walls.
Rifampcin action and main side effect
Think R R R: Rifampcin, RNA, Red
Inhibits RNA synthesis.
Side effect: Red/Orange urine, sweat, and tears.
What class of abx is Cephotaxime?
Cephalosporin
What class of abx is Vancomycin?
Glycopeptide
What class of abx is Doxycycline?
Tetracycline
What class of abx is Gentamicin?
Aminoglycoside
What class of abx is Erythromycin?
Macrolide
What class of abx is Trimethoprim?
Dihydrofolate reductase inhibitor
What class of abx is Flucloxacillin?
B-Lactam
What class of abx is Ciprofloxacin?
Quinolone
What is the action of Doxycycline?
Blocks 30S subunit of bacterial ribosomes
(Buys A[T]30 and CELLS at 50).
What is the action of Clarythromycin?
Blocks 50S subunit of bacterial ribosomes
Buys AT30 and C[E]LLS at 50
»>Referring to [E]rythromycin.
What is the action of Trimethoprim?
Inhibits dihydrofolate reductase which prevents folate metabolism which prevents DNA synthesis.
What is the action of Gentamicin?
Blocks 30S subunit of bacterial ribosomes
Buys [A]T30 and CELLS at 50
»>Reffering to [A]minoglycosides
What is a side-effect of Aminoglycosides?
Long QT > Torsades des pointes
What is the action of Vancomycin?
Prevents peptidoglycan polymerisation and thus prevents cell-wall synthesis.
What is the action of Ciprofloxacin?
Prevents DNA synthesis by inhibition of DNA gyrase and topoisomerase.
What is the action of Metronidazole?
MetroniDAzole
Damages DNA once it has been reduced (Predominantly by anaerobic organisms).
What is the action of Chlopramphenicol?
Blocks 50S subunit of bacterial ribosomes
Buys AT30 and [C]ELLS at 50
