Anti-???? Antibodies Flashcards
ANA
Anti-Nuclear Antibodies
- Present in SLE. Act as a test for SLE.
- Also present in 90% of scleroderma pt
- Also present in Sjogren’s.
p-ANCA
Perinuclear Anti-Neutrophil Cytoplasmic Antibodies
- Present in Ulcerative Collitis
- Primary sclerosing cholangitis
- EOSINOPHILIC Granulomatosis with Poly-Angitis
c-ANCA
Cytoplasmic Anti-Neutrophil Cytoplasmic Antibodies.
-80-90% of Granulomatosis with Poly-Angitis (GPA/Wegner’s Granulomatosis)
Anti-dsDNA
Anti-Double-Stranded DNA
- A type of Anti-Nuclear-Antibody (ANA)
- Highly indicative of SLE
Anti-TPO
Anti-Thyroid PerOxidase Antibodies
-Common in Hashimoto’s Thyroiditis = Hypothyroidism.
TR-Abs
Thyroid-Receptor Antibodies
-Associated with Grave’s Disease.
AMA
Anti-Mitochondrial Antibodies
-Test for Primary Billary Cirrhosis
A-TTG
Anti-Tissue Transglutaminase
-Present in coeliac disease.
A-EMA
Anti-Endomysial Antibodies
-Present in coeliac disease.
Anti-LA
AKA Anti-SSB (Anti-Sjogren’s-Syndrome B)
- A type of Anti-Nuclear-Antibody (ANA)
- Attacks La protein and causes Sjogren’s
- Raised in serum in Sjogren’s.
Anti-RO
AKA Anti-SSA (Anti-Sjogren’s-Syndrome A)
- A type of Anti-Nuclear-Antibody (ANA)
- Attacks Ro protein and causes Sjogren’s
- Raised in serum in Sjogren’s.
- Raised in Lupus (Anti-La likely not raised)
Anti-SSA
Anti Sjogren’s Syndrome A (AKA Anti-RO)
- A type of Anti-Nuclear-Antibody (ANA)
- Attacks Ro protein and causes Sjogren’s
- Raised in serum in Sjogren’s.
Anti-SSB
Anti-Sjogren’s-Syndrome B (AKA Anti-LA)
- A type of Anti-Nuclear-Antibody (ANA)
- Attacks La protein and causes Sjogren’s
- Raised in serum in Sjogren’s.
Anti-RNA Polymerase III
Associated with limited scleroderma
Anti-Centromere
A type of Anti-Nuclear-Antibody (ANA)
=Associated with diffuse scleroderma
