Module 7 - 4 Flashcards
What are glycoproteins?
Proteins with sugar groups added.
What percentage of biological proteins are modified with sugar groups?
About 50%.
What is the function of sugar group modifications?
Regulate protein structure and function.
How are sugar groups attached to proteins?
N-linked or O-linked.
A hormone that stimulates red blood cell production.
How many N-linked and O-linked glycosylations does EPO have?
Three N-linked and one O-linked.
What is the medical use of EPO?
Treatment of anemia.
How is EPO exploited by endurance athletes?
To increase oxygen carrying capacity.
How do the patterns of glycosylation differ between synthetic and endogenous EPO?
They differ.
What is the extracellular matrix?
A gel-like material in tissues.
What is the function of the extracellular matrix?
Holds cells together, provides a pathway for diffusion, and serves a cushioning function.
What are the glycosaminoglycans?
Heteropolysaccharides in the extracellular matrix.
What is the composition of the extracellular matrix?
A meshwork of fibrous proteins and glycosaminoglycans.
