module 3.2 Flashcards

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1
Q

what protein do erythrocytes contain

A

haemoglobin

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2
Q

haemoglobin + oxygen–>

A

haemoglobin + oxygen–>oxyhaemoglobin

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3
Q

what dos each haem group of haemoglobin contain

A

a single iron ion (Fe2+)

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4
Q

what can iron ions do in haemoglobin

A

attract and hold an oxygen molecule

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5
Q

what does affinity mean

A

attraction

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6
Q

what does dissociation mean in terms of haemoglobin

A

releasing the oxygen from oxyhaemoglobin

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7
Q

what is foetal haemoglobin

A

the type of haemoglobin usually only found in the foetus

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8
Q

what does haemoglobin have a HIGH affinity for

A

oxygen

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9
Q

state the process of the transport of oxygen

A

oxygen is absorbed in the blood as it passes the alveoli in the lungs . o2 molecules diffusing into the blood plasma enter the red blood cells. here they become associated with the haemoglobin (it binds reversibly ). this takes oxygen out of solution so maintains a steep conc gradient, allowing more o2 to enter the blood from the lungs and diffuse into cells.
the blood carries oxygen from the lungs back to the heart, before travelling around the body to supply the tissues. in body tissues, cells need o2 for aerobic respiration. thus haemoglobin must eb able to release oxygen (dissociate)!

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10
Q

what does the ability of haemoglobin to associate and release oxygen depend on

A

the conc of o2 in the surrounding tissues

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11
Q

what is the conc of o2 measured by

A

by the relative pressure that it contributes to a mixture of gasses. this is called the partial pressure of o2 or pO2, its also called the oxygen tension and measured in kPa

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12
Q

what sort of curve does the association of oxygen with haemoglobin create and what is this curve called

A

S-shaped curve- this is called the haemoglobin dissociation curve.

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13
Q

describe the haemoglobin dissociation curve and why its shaped like this (bottom of the curve)

A

at low oxygen tension, the haemoglobin does not readily associate with o2 molecules. This is because haem groups that attract oxygen are in the centre of the haemoglobin molecule. This makes it difficult for the o2 molecule to reach the haem group and associate with it. this difficulty in combining with 1st o2 molecule accounts for the low saturation level of haemoglobin at low o2 tensions.

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14
Q

describe the haemoglobin dissociation curve and why its shaped like this (middle of the curve)

A

as o2 tension rises, diffusion grad into haemoglobin increases. eventually, 1 o2 molecule enters haemoglobin and associates with one of the haem groups causing a conformational change allowing o2 molecules to enter haemoglobin and associate with other haem groups relatively easy.- this accounts for the steepness as the o2 tension rises

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15
Q

describe the haemoglobin dissociation curve and why its shaped like this (top of the curve)

A

as haemoglobin reaches 100% saturation, the curve levels off.

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16
Q

talk about the oxygen tension in the lungs and the oxygen tension in the respiring body tissues

A

o2 tension in the lungs is sufficient to produce close to 100% saturation. The o2 tension in respiring body cells is sufficiently low to cause oxygen to dissociate readily from the oxyhaemoglobin.

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17
Q

how is fetal hemoglobin different to adult hemoglobin- talk about curve too

A

it has a higher affinity for oxygen thus the hemoglobin dissociation curve is to the left of the adult curve.

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18
Q

why does fetal hemoglobin have a higher affinity than adult hemoglobin

A

because fetal hemoglobin must be able to associate with o2 in an environment where o2 tension is low enough to make adult hemoglobin release o2

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19
Q

in the placenta, is o2 tension low or high

A

low

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20
Q

what does the fetal hemoglobin do and what dos this do to the o2 tension. what does it do to the mothers blood

A

in the placenta where o2 tension is low, fetal hemoglobin will absorb o2 from the surrounding fluid, this reduces o2 tension even further, as a result oxygen diffuses from the mothers blood into the placenta- this reduces o2 tension within the mothers blood which makes the maternal hemoglobin release more o2 (dissociation)

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21
Q

what are the 3 ways co2 is transported

A
  • dissolved directly in placenta (5%)
    -combined with hemoglobin to form a compound called carbaminhaemoglobin (10%)
    -transported in the form of hydrogen carbonate ions (HCO3-)
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22
Q

Describe the formation of hydrogen carbonate ions (4 STEPS) (6)

A

-co2 in the blood plasma diffuses into red blood cells, here it combines with a weak acid called carbonic acid. this reaction is catalyzed by carbonic anhydrase.
CO2+H20–>H2CO3
-This carbonic acid dissociates to release H+ ions and hydrogen carbonate ions(HCO3-)
-The hydrogen carbonate ions diffuse out of the red blood cells into the plasma. the charge inside the red blood cell is maintained by the movement of cl- ions from the plasma into the red blood cell-this is the chloride shift.
-the hydrogen ions building up in the red blood cell could cause contents of red blood cell to become v acidic. to prevent this, H+ ions are taken out of solution by associating with hemoglobin to produce hemoglobinic acid. the hemoglobin is acting as a buffer

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23
Q

whats a buffer

A

a compound that maintains constant pH

24
Q

whats hemoglobinic acid

A

the compound formed by the buffering action of hemoglobin as it combines with excess H+ ions

25
Q

in the tissues, the partial pressure of o2 is lower thus oxyhemoglobin begins to dissociate and release o2 to the tissues, what dos this mean that hemoglobin is available to take and what does this mean…

A

the hemoglobin is available to take up H+ ions forming hemoglobinic acid, where tissues are very active, more co2 is released.

26
Q

what does the bohr effect describe (1)

A

describes the effect that an increasing conc of co2 has on the haemoglobin

27
Q

4 steps covering the bohr effect…

A
  • co2 enters the red blood cells forming carbonic acid, which dissociates to release H+ ions.
  • these H+ ions affect the pH of the cytoplasm, making it more acidic.
    -as with any protein, changes in pH can affect tertiary structure of the hemoglobin and reduces the affinity of the hemoglobin for o2
    -the hemoglobin is unable to hold as much o2 and o2 is released from the oxyhaemoglobin to the tissues
28
Q

where tissues are respiring more, there will be more co2- will there be more or less hydrogen ions produced in the red blood cell and what does this make oxyhemoglobin do

A

more H+ ions produced in the red blood cell making the oxyhemoglobin release more oxygen.

29
Q

overall, what does the bohr effect lead to

A

results in more o2 being released

30
Q

what happens to the hemoglobin dissociation curve in result to the bohr effect

A

shifts downwards and to the right

31
Q

what are the two main pumping chambers

A

the ventricles and the atrium

32
Q

what is situated above the ventricles

A

the atrium

33
Q

what are the atrio-ventricular valves

A

valves between the atria and ventricles which ensures that blood flows in the right direction

34
Q

whats cardiac muscle

A

specialised muscle found in the walls of the heart chambers

35
Q

semilunar valves

A

valves that prevent blood from re-entering the heart from the arteries

36
Q

what type of blood does the right side pump

A

deoxygenated blood to the lungs to get oxygenated

37
Q

what type of blood does the left side pump

A

oxygenated blood to the rest of the body

38
Q

what lie over the surface of the heart and what do they supply

A

coronary arteries that supply oxygenated blood to the heart muscle.

39
Q

what can restricted blood flow to the heart muscle cause

A

angina or heart attack.

40
Q

what do the atria receive

A

blood from major veins

41
Q

what are the two main veins leading into the atrium

A

the vena cava and the pulmonary vein

42
Q

in the vena cava what is the type of blood and where does it move

A

deoxygenated blood from the body which moves into the right atrium

43
Q

in the pulmonary vein what is the type of blood and where does it move

A

oxygenated blood from the lungs which moves into the right atrium

44
Q

what are attached to the valves and what do they do

A

tendinous chords which prevent the valves from turning inside out when the ventricle walls contract

45
Q

what does the wall of muscle called the septum do

A

separates the ventricles from each other- ensures that oxygenated blood keeps to the left side and deoxygenated blood sticks to the right side

46
Q

what type of vessel does blood leaving the heart go into

A

arteries

47
Q

where does deoxygenated blood leave and what does it go into

A

the right ventricle into the pulmonary artery

48
Q

where does oxygenated blood leave and what does it go into

A

the left ventricle into the aorta

49
Q

whats the structure and function of the atria

A
  • thin walls
  • function= receive blood from the veins and push it into the ventricles
50
Q

whats the structure and function of the right ventricle

A

-thicker than the walls of the atria
-pumps deoxygenated blood to the lungs

51
Q

whats the structure and function of the aorta

A

connected to the left of the ventricle
-carries blood away from the heart to the body

52
Q

whats the structure and function of the left ventricle

A
  • 2 or 3 times thicker than the right ventricle as a lot more pressure
    -the blood from the left ventricle is pumped out the aorta
53
Q

what does the atrioventricular valves prevent

A

prevent backflow of blood from the arteries

54
Q

what do the pulmonary veins carry

A

oxygenated blood from the lungs

55
Q

what do the pulmonary arteries carry

A

deoxygenated blood from the heart

56
Q

describe the cardiac muscle structure

A

-consists of fibres that branch making cross bridges- these help spread stimulus across the heart and the muscle can produce a squeezing action.
-numerous mitochondria between muscle fibres to supply energy for contraction.
-muscles are separated by intercalated discs which facilitate synchronised contraction, each cell has a nucleus and is divided into contractile units called sarcomeres