Mixed 36

Question 1

Duchenne muscular dystrophy is caused by what type of mutation

Answer 1

Frameshit deletion or nonsense mutation (early stop codon)

Question 2

Clinical manifestations at a fibular neck fracture or compression

Answer 2

Injury of the common fibular nerve:
weaknes on foot dorsiflexion and eversion,
impaired sensation of lateral shin, dorsal foot

Question 3

In a px with major depressive disorder, what do we have to rule out before starting monotherapy?

Answer 3

Screening for previous maniac of hypomaniac episodes to rule out bipolar disorder

Question 4

Mechanism of action of Latanoprost in glaucoma therapy

Answer 4

Topical prostaglandin that ↑ outflow of aqueous humor via ↓ resistance of flow through uveoscleral pathway

Question 5

Mechanism of action on opioid analgesics

Answer 5

Agonists at opioid receptors: ↓ synaptic transmission by closing presynaptic Ca2+ channels and opening postsynaptic K+ channels

Question 6

Immunologic response of inactivated viral vaccines

Answer 6

Humoral response: Ab vs extracellular viral antigens → preventing viral entry to the cell

Question 7

Clinical findings of Galactokinase deficiency

Answer 7

Galactitiol accumulates. Galactosemia, galactosuria, infantile cataracts