Mixed 33

Question 1

Main functions of the Sertoli cells

Answer 1

Produce anti-Müllerian hormone → supress female internal reproductive organs
Secrete inhibin B → inhibits FSH
Secrete androgen-binding protein → maintain local levels of testosterone

Question 2

Main functions of the Leydig cells

Answer 2

Secrete testosterone → development of internal male reproductve organs (by Wolffian duct stimulation) and external male reproductive organs (by dihydrotestosterone conversion)

Question 3

Huntington disease triad

Answer 3

Movement disorder, behavioral abnormalities and dementia

Question 4

Genetic phenomenon characterized by the tendency of clinical symptoms to worsen and/or occur earlier in subsequent generations

Answer 4

Anticipation. Commonly seen in trinucleotide repeat diseases

Question 5

Immune phenomenon caused by Epstein Barr virus that by infecting B cells stimulate them to proliferate indefinitely and maintain Ig production

Answer 5

Immortalization

Question 6

The more accurate stadistic test is…

Answer 6

the closer area under the curve value is to 1.0

Question 7

Methylmalonic acidemia clinical features

Answer 7

Poor feeding, vomiting, hypotonia.
High anion gap metabolic acidosis, hypoglycemia, ketosis, hyperammonemia
↑ urine methylmalonic acid and propionic acid

Question 8

Immunologic response in Staphylococcal toxic shock syndrome by TSST-1 superantigen

Answer 8

Binds to MCH II and T-cell receptor, resulting in polyclonal T-cell activation and cytokine release

Question 9

Monoclonal antibody directed against CD20 antigen

Answer 9

Rituximab