Mitosis Flashcards
Prophrase
Chromosome condense (thicker/shorter)
= 2 sister chromatids, joined by centromeres
-nuclear envelope breaks down
-centrioles begin to pull apart move to opposite poles forming the spindle
Metaphrase
Chromosomes align along the equator of the cell
-spindle fibre attach to chromosome by centromeres
Anaphase
Chromatids from each pair are pulled, centromeres first towards opposite poles of the cell
Spindle fibre contract —> pull chromatids to opposite poles of the cell by the overlapping fibre contract and cause the movement of the chromatids supplied by ATP
Centromeres divides
Telephrase (two)
Chromosomes uncoil (longer/thinner) and separate becoming less dense
Nuclear envelope reforms = 2 nuclei
Spindle fibres & centrioles break down
Interphrase
Growing
Replicating DNA
Carry out normal cellular activities
G1
PREPARATION -organelle replicates - increase cell size -protein synthesis —> respiration
A signal is received telling the cells to divide again
This phrase of the interphase stage of the cell cycle is called the S phrase (synthesis of DNA) (relatively short)
Chromosomes replicate and become doubled stranded chromatids
- cells make the RNA, enzymes and other proteins required for growth during the G1 phase
G2
The cell continues to grow and the new DNA that has been synthesised is checked and any error are usually repaired
What makes up interphase
G1+ S+ G2
Mitosis
Nucleus is actively dividing
Cytokinesis
New cell divides in the cytoplasm
Checkpoints
G1 checkpoint - cell size? DNA damage?
If not then goes into G0 ( cell leaves the cell cycle)
G2 checkpoint - DNA replication error
What happens in G0
Differentiate, (muscle cell)
die,
enter senescence (where they stop dividing) (ageing)
Why does mitosis happen
Repair
Growth
Asexual reproduction