Miscellaneous Antibacterial

Question 1

glycopeptides (vancomycin) inhibit the synthesis of ____ ____ by interfering with cell wall _____

Answer 1

cell wall

precursors

Question 2

vancomycin is generally considered ________

Answer 2

bacteriocidal

Question 3

all gram negatives and TB (mycobacteria) are ________ to vancomycin

Answer 3

resistant

Question 4

vancomycin is great for ____________ and serious conditions like ______

Answer 4

MSSA, MRSA

endocarditis

Question 5

Fluroquinoloes (cipro) are _______ and work by inhibiting __________ and ______

Answer 5

bactericidal

DNA gyrase and DNA synthesis

Question 6

Fluoroquinolones are excellent for __________ and atypicals

Answer 6

gram negatives!!

Question 7

_______ work well on shigella, enterbacter, campylobacter, neisseria. Also work well for _______

Answer 7

fluoroquinolones (cipro)

UTIs

Question 8

biggest problem with fluoroquinolones is ___________

Answer 8

tendon rupture

Question 9

sulfonamides (folate antagonists) prevent __________

Answer 9

PABA (in DNA synthesis)

Question 10

sulfa drugs inhibit both ________ and _______

Answer 10

gram negative and gram positive

Question 11

sulfa drugs are often used for _______

Answer 11

UTIS

Question 12

toxic epidermal necrolysis is a problem with ______

Answer 12

sulfa drugs

Question 13

Trimethoprim concentrate in prostatic and vaginal fluid, so is also used for _______

Answer 13

UTIs and prostatitis

Question 14

trimethoprim is more ______ than SMX, so they are often added

Answer 14

lipid soluble

Question 15

Metronidazole is a __________ that is used to “clean up” organisms that the other drug classes cant

Answer 15

nitroimidazole

Question 16

metronidazole is great at taking care of ______, _____, and ______

Answer 16

anaerobes and parasistes

C difficile

Question 17

metronidazole would NOT be used for ______, but good for gram neg and pos ______

Answer 17

staph, strep, e coli

anaerobes (bacteriodes, clostridium)

Question 18

metronidazole is a ______, so it requires reductive activation

Answer 18

prodrug

Question 19

black box warning for metronidazole may be ________. May also cause _______ _____

Answer 19

carcinogenic

peripheral neruopathy

Question 20

notorious drug interaction with metronidazole is ________

Answer 20

ALCOHOL!